rs1255327081
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two point mutations in MHS alpha- (F316Y) and beta- (Q529R) adducin genes have been shown to be associated with hypertension in genetic crosses of MHS and MNS rats.
|
9678591 |
1998 |
rs16843452
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MDR analysis indicated that interaction among BMI, rs4963, and rs16843452 were involved in susceptibility of hypertension.
|
23509723 |
2013 |
rs372777117
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two point mutations in MHS alpha- (F316Y) and beta- (Q529R) adducin genes have been shown to be associated with hypertension in genetic crosses of MHS and MNS rats.
|
9678591 |
1998 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ADD1 G460W-dominant model for the G allele was significantly associated with hypertension of IgAN patients (P = 0.001, Pc = 0.031 and OR = 1.37).
|
24271554 |
2014 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Gly460Trp variant of the alpha-adducin gene has been associated with renal sodium retention and salt-sensitive hypertension.
|
18458162 |
2008 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study examined the SNPs AGT rs699 (Met235Thr), ADD1 rs4961 (Gly460Trp), NPPA rs5063 (Val32Met), GPX1 rs1050450 (Pro198Leu), and AGTR1 rs5186 (A1166C) in relation to hypertension and salt sensitivity.
|
27480094 |
2017 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that the α-adducin rs4961 polymorphism may serve as a genetic biomarker of HTN in Asians.
|
30552709 |
2019 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
More studies based on a larger population are required to evaluate further the role of alpha-adducin Gly460Trp polymorphism in salt-sensitive hypertension.
|
20145305 |
2010 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest that the Gly460Trp polymorphism of ADD-1 is not associated with hypertension.
|
15608390 |
2004 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that the Gly460Trp polymorphism might increase the risk of hypertension in Chinese populations, especially in Han Chinese.
|
21228790 |
2011 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results rather suggest that another variant in linkage disequilibrium with the Gly460Trp polymorphism increases susceptibility for hypertension.
|
10673730 |
2000 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We recently found that femoral intima media thickness, as well as the incidence of hypertension, is influenced by genes encoding the angiotensin-converting enzyme (ACE; insertion/deletion [I/D]) polymorphism, alpha-adducin (Gly460Trp), and aldosterone synthase (-344C/T).
|
11728946 |
2001 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our case-control study and the following meta-analysis failed to provide evidence for the genetic association of alpha-adducin gene G460W polymorphism with hypertension.
|
19960031 |
2010 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A recent report by Cusi et al showed that the Trp allele of alpha-adducin polymorphism (Gly 460 Trp) is associated with an increased risk of hypertension in whites, which led us to carry out a case-control study to examine whether the same association is observed in the Japanese population.
|
9607391 |
1998 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ADD1 Gly460Trp polymorphism is associated with salt-sensitive hypertension and increased Na-K pump activity in transfected cells.
|
18667944 |
2008 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The alpha-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure.
|
17472579 |
2007 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, 3 physiologically important candidate gene mutations (angiotensinogen A[-6], alpha-Adducin Gly460Trp, and G-Protein beta(3)-subunit C825T) were examined for their association with hypertension status in a sample of 904 African Americans from Jackson, Mississippi.
|
10856280 |
2000 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additional studies have suggested that a polymorphism within exon 10 of the human alpha-adducin gene (Gly-460-Trp) may be associated with hypertension and salt sensitivity.
|
10912756 |
2000 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hence, no evidence was found to suggest an association between either the alpha-adducin G460W or the ACE I/D polymorphism and hypertension in a careful case-control study.
|
11116113 |
2000 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An interaction with hypertension in the association between the ADD1 G460W polymorphism and cardiovascular disease merits further testing in additional populations.
|
12052841 |
2002 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women (P=0.03124; OR=1.584).
|
23122309 |
2012 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Also in humans, a polymorphism of alpha-adducin gene (Gly460Trp) has been found to be significantly associated both to hypertension and salt sensitivity.
|
9678591 |
1998 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest the possibility that the Gly460Trp polymorphism of ADD-1 is associated with low renin hypertension.
|
12195119 |
2002 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On the other hand, the Gly460Trp genotype of the alpha-adducin gene (ADD1) is associated with erythrocyte sodium transport and increases tubular sodium reabsorption and risk for hypertension.
|
12924618 |
2003 |
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this short editorial review, we summarize the recent experimental, clinical and epidemiological evidence that contributed to our understanding of the pathogenetic mechanisms that lead to hypertension associated with the alpha-adducin Gly460Trp polymorphism and its interaction with ouabain.
|
16207143 |
2005 |