|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease.
|
21816783 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of 35 genetic association studies that examined the relation between hypertension and the G894T, 4a/b, T786C, and G23T polymorphisms of the endothelial nitric oxide synthase gene was carried out.
|
16940230 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of endothelial nitric oxide synthase (eNOS) gene G894T polymorphism with hypertension risk and complications.
|
27557897 |
2016 |
|
rs891512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of the intronic polymorphism rs891512 (G24943A) of the endothelial nitric oxide synthase gene with hypertension in Chilean type 2 diabetes patients.
|
22425436 |
2012 |
|
rs368332097
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Each analysis consistently revealed the 46A allele of ADRB2 46G/A SNP and 4a allele of NOS3 4b/4a SNP to be associated with risk of hypertension.
|
25159081 |
2015 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
For hypertension associations were seen for additional SNPs including NOS3 SNP rs3918226, previously associated with hypertension in genome-wide association study (GWAS) data.
|
24713495 |
2014 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further studies are needed to reveal the usefulness of G894T polymorphism in hyper</span>tension risk assessment in obese.
|
26579574 |
2015 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, meta-regression analysis indicated that the effect of the Glu298Asp genotype on the risk of hypertension might be dependent on total cholesterol status.
|
17762636 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotype frequencies for the -786T/C, 4b/4a, and 894G/T polymorphisms differed significantly (P<0.001) between patients and controls and were associated with an increased risk of hypertension (OR=2.0, OR=3.8, OR=1.6, respectively).
|
18325347 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, a subgroup analysis adjusted with various cardiovascular risk factors confirmed positive association of the -786T>C polymorphism in CAD patients with hypertension and a smoking history and also a significant association of the intron 4 genotypes with a smoking history, but no significance has been found in the eNOS polymorphisms of 894G>T upon any risk adjustment.
|
16842840 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, GG phenotype of Glu298Asp polymorphism neither decreased the ESRD risk (OR = 0.77, 95% CI 0.55-1.08, P = 0.13) nor affected the hypertension risk (OR = 1.04, 95% CI 0.66-1.66, P = 0.86).
|
24995932 |
2014 |
|
rs3918188
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity.
|
24943287 |
2015 |
|
rs743506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity.
|
24943287 |
2015 |
|
rs7830
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity.
|
24943287 |
2015 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, a missense Glu298Asp mutation in exon 7 of the eNOS gene is reported to be a risk factor for hypertension or myocardial infarction.
|
12701818 |
2003 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, rs3918226 in the eNOS promoter tags a hypertension susceptibility locus, TT homozygosity being associated with lesser transcription and higher risk of hypertension.
|
24019403 |
2013 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Intron 4 B/B genotype was significantly associated with the hypertension group (P = 0.035), but disequilibrium of G894T and T-786C was absent between the two groups (P = 0.419 and P = 0.227), respectively.
|
17024134 |
2006 |
|
rs891511
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.
|
27618448 |
2016 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multiple logistic regression revealed that the most predictive independent risk factor for coronary spasm was the T-786-->C mutation (P < 0.001), followed by cigarette smoking (P < 0.001), hypertension (P = 0.004), and the Glu298Asp variant (P = 0.028).
|
10979242 |
2000 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients.
|
19650939 |
2009 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist.
|
19169496 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, our findings suggest that eNOS G894T and T-786C SNPs were both significantly correlated with hypertension</span>.
|
28287883 |
2017 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies regarding endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism focused upon its relation to hypertension.
|
17594145 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a G894T polymorphism in exon 7 of the eNOS gene has been reported to be associated with high blood pressure.
|
18164968 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Regarding the eNOS E298D polymorphism, the frequency of the mutant D allele carriage was only observed to be higher among cases with hypertension associated with diabetes and obesity, in comparison with controls, yet not reaching statistical significance (41.2% vs. 34%, p > 0.05).
|
23042814 |
2013 |