|
rs891511
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.
|
27618448 |
2016 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, a subgroup analysis adjusted with various cardiovascular risk factors confirmed positive association of the -786T>C polymorphism in CAD patients with hypertension and a smoking history and also a significant association of the intron 4 genotypes with a smoking history, but no significance has been found in the eNOS polymorphisms of 894G>T upon any risk adjustment.
|
16842840 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of endothelial nitric oxide synthase (eNOS) gene G894T polymorphism with hypertension risk and complications.
|
27557897 |
2016 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further studies are needed to reveal the usefulness of G894T polymorphism in hyper</span>tension risk assessment in obese.
|
26579574 |
2015 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Glu298Asp, T786C and 4a/4b genetic polymorphisms within the endothelial nitric oxide synthase (e-NOS) gene may predispose to hypertension, ischaemic heart disease and renal damage, possibly by reducing the generation of nitric oxide (NO), a fundamental substance in renal and cardiovascular biology.
|
17563560 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggested no association between the Glu298Asp gene polymorphism and the incidence of hypertension in this selected population.
|
15475025 |
2004 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20083095 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The relevance of the Glu298Asp polymorphism to hypertension in this population was tested in 2 ways.
|
10205226 |
1999 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on the associations between the nitric oxide synthase gene (NOS3) Glu298Asp polymorphism and hypertension status or blood pressure (BP) levels have had inconsistent results.
|
15505116 |
2004 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genotypic distribution of the Met235Thr (AGT) and Glu298Asp (NOS3) polymorphisms demonstrated that both are independent risk factors of hypertension (p=0.02 and p=0.008, respectively).
|
22791701 |
2013 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The AGT M235T and eNOS G894T polymorphisms are unlikely to play an important role in the pathogenesis of hypertension in Malays.
|
17977523 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of 35 genetic association studies that examined the relation between hypertension and the G894T, 4a/b, T786C, and G23T polymorphisms of the endothelial nitric oxide synthase gene was carried out.
|
16940230 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotype frequencies for the -786T/C, 4b/4a, and 894G/T polymorphisms differed significantly (P<0.001) between patients and controls and were associated with an increased risk of hypertension (OR=2.0, OR=3.8, OR=1.6, respectively).
|
18325347 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Relation of the Glu298Asp polymorphism of the nitric oxide synthase gene to hypertension and serum cholesterol in Japanese workers.
|
18550157 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our study is to investigate whether genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (in the promoter region T(-786)C, in exon 7 (Glu298Asp) and in intron 4 (4b/4a)) or eNOS haplotypes are associated with hypertension in obese children and adolescents.
|
20661250 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients.
|
19650939 |
2009 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, our findings suggest that eNOS G894T and T-786C SNPs were both significantly correlated with hypertension</span>.
|
28287883 |
2017 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multiple logistic regression revealed that the most predictive independent risk factor for coronary spasm was the T-786-->C mutation (P < 0.001), followed by cigarette smoking (P < 0.001), hypertension (P = 0.004), and the Glu298Asp variant (P = 0.028).
|
10979242 |
2000 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results do not support the hypothesis that the E298D polymorphism contributes to the genetic susceptibility to hypertension.
|
15942458 |
2005 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, a missense Glu298Asp mutation in exon 7 of the eNOS gene is reported to be a risk factor for hypertension or myocardial infarction.
|
12701818 |
2003 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We, via a comprehensive meta-analysis, ascertained the role of eNOS G894T and 4b/a polymorphisms on hypertension in Asians, and T-786C polymorphism in Whites.
|
21912683 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a G894T polymorphism in exon 7 of the eNOS gene has been reported to be associated with high blood pressure.
|
18164968 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The NOS3 -786 T/C (SNP id rs2070744; http://www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease.
|
21293869 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The relationship between the G894T polymorphism and hypertension in Han Chinese may be attributed to the difference in geographic background of subjects.
|
24846690 |
2015 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We revealed that a combination of the Arg16Gly and Glu298Asp polymorphisms in ADRB2 and NOS3, respectively, remarkably increased the risk for hypertension in middle-aged and elderly humans.
|
19373110 |
2009 |