|
rs1801282
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Association between peroxisome proliferator-activated receptor γ-2 gene Pro12Ala polymorphisms and risk of hypertension: an updated meta-analysis.
|
30777927 |
2019 |
|
rs1801282
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The results indicated the significant association of PPARγ2 rs1801282 polymorphism with hypertension susceptibility among East Asians.
|
22561695 |
2012 |
|
rs1801282
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis.
|
19766907 |
2009 |
|
rs1801282
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We randomly recruited 251 nuclear families (433 parents and 493 offspring) in the framework of the European Project on Genes in Hypertension study and genotyped 926 participants in whom all serum lipid variables and information on alcohol consumption were available for PPARgamma2 Pro12Ala.
|
15716591 |
2005 |
|
rs1801282
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Peroxisome proliferator-activated receptor-gamma2 Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are not associated with hypertension in diabetes mellitus type 2.
|
15662218 |
2005 |
|
rs1801282
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The data suggest a contribution of the Pro12Ala polymorphism of PPARgamma to genetic susceptibility to type 2 diabetes mellitus and hypertension, but not to insulin sensitivity in hypertensive subjects.
|
15563983 |
2004 |
|
rs1801282
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population.
|
11248748 |
2001 |
|
rs1805192
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Association between peroxisome proliferator-activated receptor γ-2 gene Pro12Ala polymorphisms and risk of hypertension: an updated meta-analysis.
|
30777927 |
2019 |
|
rs1805192
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis.
|
19766907 |
2009 |
|
rs1805192
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We randomly recruited 251 nuclear families (433 parents and 493 offspring) in the framework of the European Project on Genes in Hypertension study and genotyped 926 participants in whom all serum lipid variables and information on alcohol consumption were available for PPARgamma2 Pro12Ala.
|
15716591 |
2005 |
|
rs1805192
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Peroxisome proliferator-activated receptor-gamma2 Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are not associated with hypertension in diabetes mellitus type 2.
|
15662218 |
2005 |
|
rs1805192
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The data suggest a contribution of the Pro12Ala polymorphism of PPARgamma to genetic susceptibility to type 2 diabetes mellitus and hypertension, but not to insulin sensitivity in hypertensive subjects.
|
15563983 |
2004 |
|
rs1805192
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population.
|
11248748 |
2001 |
|
rs1175543
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, among the eight SNPs not individually associated with hypertension (rs12631819, rs2920502, rs1175543, and rs2972164 in the PPARG gene, and rs2638360, rs1492100, rs5182, and rs275646 in the AGTR1 gene), the two-locus model involving rs12631819 and rs5182 demonstrated increased susceptibility to hypertension, and the five-locus model involving rs12631819, rs2920502, rs2972164, rs5182, and rs2638360 demonstrated a significantly decreased risk of hypertension.
|
29266977 |
2018 |
|
rs12631819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, among the eight SNPs not individually associated with hypertension (rs12631819, rs2920502, rs1175543, and rs2972164 in the PPARG gene, and rs2638360, rs1492100, rs5182, and rs275646 in the AGTR1 gene), the two-locus model involving rs12631819 and rs5182 demonstrated increased susceptibility to hypertension, and the five-locus model involving rs12631819, rs2920502, rs2972164, rs5182, and rs2638360 demonstrated a significantly decreased risk of hypertension.
|
29266977 |
2018 |
|
rs2972164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, among the eight SNPs not individually associated with hypertension (rs12631819, rs2920502, rs1175543, and rs2972164 in the PPARG gene, and rs2638360, rs1492100, rs5182, and rs275646 in the AGTR1 gene), the two-locus model involving rs12631819 and rs5182 demonstrated increased susceptibility to hypertension, and the five-locus model involving rs12631819, rs2920502, rs2972164, rs5182, and rs2638360 demonstrated a significantly decreased risk of hypertension.
|
29266977 |
2018 |
|
rs3856806
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MB-MDR analyses suggested that the two-locus model (rs9817428 and rs2933249) and the three-locus model (rs9817428, rs3856806, and rs2933249) were significantly associated with a decreased risk of hypertension.
|
29266977 |
2018 |
|
rs9817428
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MB-MDR analyses suggested that the two-locus model (rs9817428 and rs2933249) and the three-locus model (rs9817428, rs3856806, and rs2933249) were significantly associated with a decreased risk of hypertension.
|
29266977 |
2018 |
|
rs12633551
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP rs6802898 was associated with hypertension in both dominant (P = 0.033) and additive models (P = 0.026) in the Han population, whereas the SNP rs12633551 was associated with hypertension in both dominant (P = 0.014) and additive models (P = 0.0073) in the Mongolian population.
|
26782582 |
2015 |
|
rs6802898
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP rs6802898 was associated with hypertension in both dominant (P = 0.033) and additive models (P = 0.026) in the Han population, whereas the SNP rs12633551 was associated with hypertension in both dominant (P = 0.014) and additive models (P = 0.0073) in the Mongolian population.
|
26782582 |
2015 |
|
rs121909244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A dominant negative P467L mutation in the ligand-binding domain of PPARgamma in humans is associated with severe insulin resistance and hypertension.
|
15254591 |
2004 |