|
rs964184
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Sixteen SNPs were significantly associated with an increased risk of HTG development, with odds ratios (ORs) (95% confidence interval [CI]) varying from 1.40 (1.01-1.95) to 4.69 (3.29-6.68) (rs964184 within the APOA5 gene).
|
31222479 |
2019 |
|
rs964184
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Multivariate logistic regression analysis with adjustment for age, gender and body mass index revealed that rs964184 of ZPR1 (P=5.1x10‑7; odds ratio, 1.37; dominant model), rs4845625 of IL6R (P=0.0019, odds ratio, 1.25; dominant model) and rs46522 of UBE2Z (P=0.0039, odds ratio, 1.19; dominant model) were significantly associated with hypertriglyceridemia, and that rs599839 of PSRC1 (P=0.0004, odds ratio, 0.70; dominant model) and rs2075650 of TOMM40 (P=0.0004, odds ratio, 1.43; dominant model) were significantly associated with hyper‑LDL‑cholesterolemia.
|
26238946 |
2015 |
|
rs964184
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The G-G-A-A-C-C haplotype, carrying rs964184-G-allele, was associated with increased risk of HCH (OR: 1.35, 95% CI: 1.10, 1.66, P = 0.005) and HTG (OR: 1.75, 95% CI: 1.39, 2.21, P = 0.000).
|
24780069 |
2014 |
|
rs1260326
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Once demographics, medication use and baseline adiposity, and fitness were accounted for, ILI did not modify the baseline association of GCKR-Leu446Pro with elevated triglycerides (β±SE=0.067±0.013, P=1.5×10(-7) and β±SE=0.052±0.015, P=5×10(-4)) or with elevated CRP (β±SE=0.136±0.034, P=5.1×10(-5)and β±SE=0.903±0.038, P=0.015) in the overall sample and Non-Hispanic Whites, respectively.
|
26578543 |
2016 |
|
rs1260326
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Recently, the single nucleotide polymorphism (SNP) identified as rs1260326, in the glucokinase regulatory protein (GCKR), was associated with hypertriglyceridemia in adults.
|
22105854 |
2012 |
|
rs780094
|
|
|
0.730 |
GeneticVariation |
BEFREE |
The T2D risk alleles of rs972283 near KLF14 and rs11634397 near ZFAND6 were associated with a higher risk for elevated triglycerides (rs972283: 1.11 (1.02, 1.24), P = 1.46 × 10-2; rs11634397: 1.14 (1.00, 1.29), P = 4.66 × 10-2), while the T2D risk alleles of rs780094 in GCKR and rs7903146 in TCF7L2 were related to a lower risk of elevated triglycerides (rs780094: 0.86 (0.80, 0.93), P = 1.35 × 10-4; rs7903146: 0.82 (0.69, 0.98), P = 3.18 × 10-2).
|
26599349 |
2015 |
|
rs780094
|
|
|
0.730 |
GeneticVariation |
BEFREE |
GCKR rs780094 was also associated with decreased plasma glucose, and increased triglycerides in the patient and control groups.
|
24785259 |
2014 |
|
rs780094
|
|
|
0.730 |
GeneticVariation |
BEFREE |
The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population.
|
20574426 |
2010 |
|
rs17145738
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Variants more frequently identified in isolated hypertriglyceridemias were rs7412 in APOE and rs1800795 in IL6; rs2808607 in CYP7A1 and rs3812316 and rs17145738 in MLXIPL were more frequent in FCHL.
|
25176936 |
2014 |
|
rs2075291
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In summary, magnolol could effectively lower the plasma triglyceride levels in APOA5 c.553G>T variant carrier mice and facilitate the triglyceride metabolism in postprandial hypertriglyceridemia.
|
29425239 |
2018 |
|
rs2075291
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The -1131T>C and c.553G>T polymorphisms were associated with hypertriglyceridemia in the study population, but only the -1131T>C polymorphism directly affected apoA5 concentrations.
|
29211729 |
2017 |
|
rs2075291
|
|
|
0.080 |
GeneticVariation |
BEFREE |
To measure the correlation between the c.553G>T polymorphism and HTG susceptibility, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
|
27813673 |
2016 |
|
rs2075291
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Only APOA5 c.553 G ＞ T (rs2075291), resulting in the amino acid mutation Gly185Cys, co-segregated well with hypertriglyceridemia in terms of autosomal recessive inheritance (homozygote TT: mean triglyceride level: 1,071 mg/dL vs non TT (GT and GG): mean triglyceride level: 118 mg/dL; p ＜ 0.001) in the index family.
|
25843152 |
2015 |
|
rs2075291
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291).
|
25127531 |
2014 |
|
rs2075291
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Association of single-nucleotide polymorphism 3 and c.553G>T of APOA5 with hypertriglyceridemia after treatment with highly active antiretroviral therapy containing protease inhibitors in hiv-infected individuals in Taiwan.
|
19187029 |
2009 |
|
rs2075291
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The -1131T>C and c.553G>T (G185C) polymorphisms correlated with HTG in this Japanese population, but neither polymorphism directly affected ApoA5 expression.
|
17457003 |
2007 |
|
rs2075291
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These findings suggest the possible use of c.553G>T polymorphisms in APOA5 as prognostic indicators for hypertriglyceridemia susceptibility in Chinese.
|
12915450 |
2003 |
|
rs268
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Body mass index, insulin resistance, mutations in other candidate genes (Asn291Ser and Asp9Asn in the LPL gene, apoE isoforms, polymorphisms in the apoA-II gene and in the apoAI-CIII-AIV gene cluster, and in the IRS-1 gene) could be ruled out as possible factors contributing to the expression of hypertriglyceridemia in this family.
|
10787434 |
2000 |
|
rs268
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In the FOS sample, the D9N and N291S alleles were associated with lower high-density lipoprotein-cholesterol (HDL-C) (delta = - 0.07 mmol/ 1, p = 0.03) and a trend towards increased triglycerides (delta = 0.25 mmol/ 1, p = 0.07).
|
10636448 |
1999 |
|
rs268
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This difference was due to the higher frequency of the minor allele of Asn-291-->Ser in the cohort with persistent hypertriglyceridaemia compared with the control group (0.088 vs. 0.013, chi(2) = 8.00, P < 0.01).
|
9395789 |
1997 |
|
rs268
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Linkage analysis revealed no significant relationship between the D9N or N291S LPL gene mutations and the FCH phenotype (hypertriglyceridaemia, hypercholesterolaemia or increased apo B concentrations).
|
8872057 |
1996 |
|
rs268
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Heterozygosity for Asn291-->Ser mutation in the lipoprotein lipase gene in two Finnish pedigrees: effect of hyperinsulinemia on the expression of hypertriglyceridemia.
|
8732773 |
1996 |
|
rs268
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This study was carried out in order to determine the prevalence of these three mutant LPL alleles, and of a fourth encoding LPL Asn291-->Ser, in French Canadian patients with hypertriglyceridemia.
|
7706936 |
1995 |
|
rs3135506
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Various studies have identified a number of common (APOA5 c.56C>G; p.S19W; rs 3135506 ) and rare variants in the APOA5 gene in individuals with hypertriglyceridemia.
|
22914599 |
2012 |
|
rs3135506
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Various studies have identified a number of common (APOA5 c.56C>G; p.S19W; rs 3135506 ) and rare variants in the APOA5 gene in individuals with hypertriglyceridemia.
|
22914599 |
2012 |