rs1353428252
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The RHOA G17V mutation serves as a useful biomarker for cytological assessment in AITL.
|
31394087 |
2019 |
rs1353428252
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Expression of TFH Markers and Detection of RHOA p.G17V and IDH2 p.R172K/S Mutations in Cutaneous Localizations of Angioimmunoblastic T-Cell Lymphomas.
|
28945625 |
2017 |
rs1353428252
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Recent genetic studies identified that the disease-specific G17V RHOA mutation, together with mutations in TET2, DNMT3A, and IDH2, is a hallmark of angioimmunoblastic T cell lymphomas (AITL).
|
28634614 |
2017 |
rs1353428252
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Genome wide sequencing studies have dissected the repertoire of the genetic alterations driving AITL uncovering a highly recurrent Gly17Val somatic mutation in the small GTPase RHOA and major role for mutations in epigenetic regulators, such as TET2, DNMT3A and IDH2, and signaling factors (e.g., FYN and CD28).
|
27177312 |
2016 |
rs1353428252
|
|
|
0.060 |
GeneticVariation |
BEFREE |
These analyses identified highly recurrent epigenetic factor mutations in TET2, DNMT3A and IDH2 as well as a new highly prevalent RHOA mutation encoding a p.Gly17Val alteration present in 22 of 35 (67%) angioimmunoblastic T cell lymphoma (AITL) samples and in 8 of 44 (18%) PTCL, not otherwise specified (PTCL-NOS) samples.
|
24413734 |
2014 |
rs1353428252
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Here we report somatic RHOA mutations encoding a p.Gly17Val alteration in 68% of AITL samples.
|
24413737 |
2014 |
rs121913503
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Expression of TFH Markers and Detection of RHOA p.G17V and IDH2 p.R172K/S Mutations in Cutaneous Localizations of Angioimmunoblastic T-Cell Lymphomas.
|
28945625 |
2017 |
rs121913503
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.
|
27956631 |
2016 |
rs1057519736
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report the first case of discordant intracellular and plasma D-2HG levels in a patient with IDH2 R172S mutated AITL.
|
26617922 |
2015 |