Gene: LOX ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800449
rs1800449
LOX
0.030 GeneticVariation BEFREE Our study demonstrated that the LOX rs1800449 genotypes (AA and GA + AA) and allele (A) appears to confer risk for susceptibility to keratoconus. 24502826

2015
dbSNP: rs1800449
rs1800449
LOX
0.030 GeneticVariation BEFREE In contrast, our study lacked sufficient evidences to support the association of rs1800449/rs2288393 with keratoconus across populations. 26713757

2015
dbSNP: rs2288393
rs2288393
LOX
0.030 GeneticVariation BEFREE The current study aimed to investigate the possible associations between two LOX polymorphisms, rs1800449 and rs2288393, and susceptibility to keratoconus. 24502826

2015
dbSNP: rs2288393
rs2288393
LOX
0.030 GeneticVariation BEFREE In contrast, our study lacked sufficient evidences to support the association of rs1800449/rs2288393 with keratoconus across populations. 26713757

2015
dbSNP: rs2956540
rs2956540
LOX ; SRFBP1
0.030 GeneticVariation BEFREE This meta-analysis suggested that two LOX variants, rs2956540 and rs10519694, may affect individual susceptibility to keratoconus, while distinct heterogeneity existed within this locus. 26713757

2015
dbSNP: rs2956540
rs2956540
LOX ; SRFBP1
0.030 GeneticVariation BEFREE SNP rs1324183 located in MPDZ-NF1B was associated with an increased risk of KC (OR=3.108, 95% CI=1.366-7.072, p=0.005), and SNP rs2956540 in the LOX gene may confer a reduced risk of KC with a borderline p value in our population (OR=0.664, 95% CI=0.447-0.986, p=0.042). 25675348

2015
dbSNP: rs2956540
rs2956540
LOX ; SRFBP1
0.030 GeneticVariation BEFREE This first independent association validation of rs2956540:G>C and rs3735520:G>A suggests that these SNPs may serve as genetic risk markers for KC in individuals of European descent. 25735481

2015
dbSNP: rs1800449
rs1800449
LOX
0.030 GeneticVariation BEFREE Sequencing of LOX exons in a subset of keratoconus patients identified two polymorphisms, rs1800449 and rs2288393, located in LOX transcripts I and II, associated with keratoconus in case-control and family samples with a meta P value of 0.02. 22661479

2012
dbSNP: rs2288393
rs2288393
LOX
0.030 GeneticVariation BEFREE Sequencing of LOX exons in a subset of keratoconus patients identified two polymorphisms, rs1800449 and rs2288393, located in LOX transcripts I and II, associated with keratoconus in case-control and family samples with a meta P value of 0.02. 22661479

2012
dbSNP: rs10519694
rs10519694
LOX ; SRFBP1
0.010 GeneticVariation BEFREE This meta-analysis suggested that two LOX variants, rs2956540 and rs10519694, may affect individual susceptibility to keratoconus, while distinct heterogeneity existed within this locus. 26713757

2015