|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic variants of ACE (Insertion/Deletion) and AGT (M268T) genes in patients with diabetes and nephropathy.
|
24737640 |
2014 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To assess the antiproteinuric response to multifactorial treatment based on high doses of angiotensin II receptor antagonists (ARBs) (olmesartan) in patients with non-diabetic proteinuric nephropathies, according to three renin-angiotensin system (RAS) polymorphisms: insertion/deletion of the angiotensin converting enzyme (ACE) gene, the angiotensinogen gene M235T and the angiotensin II type 1 receptor (AT1R) A1166C.
|
24241364 |
2013 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of the angiotensinogen M235T and APO E gene polymorphisms in Turkish type 2 diabetic patients with and without nephropathy.
|
21500980 |
2011 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ACE ID/DD genotypes in combination with ACE rs4311, rs4343, and AGT rs699 mutant genotypes increased the risk of DNP development fourfold (p < 0.01).
|
19108684 |
2009 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There were no differences in the frequencies of the AGT M235T and ACE I/D genotypes between Turkish patients with type 2 DM with and without nephropathy.
|
18413162 |
2008 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three SNPs within the AGT, including M235T and one SNP in the AGTR1, were also significantly associated with nephropathy (M235T P=0.01, odds ratio =0.74, 95% CI 0.59-0.94).
|
17143591 |
2007 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The allele frequencies of AGT point mutation at 235 (M235T) was significantly higher in DM nephropathy but the genotypic frequencies were not.
|
12728975 |
2003 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ACE-I/D polymorphism was shown to be a risk factor of progression of renal disease and the AGT-M235T polymorphism was associated with the severity of arterial hypertension.
|
14610337 |
2003 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, the angiotensinogen (AGT) gene, M235T, and angiotensin II type 1 receptor (ATR) gene, A1166C, polymorphisms have been associated with the susceptibility to develop hypertension and renal disease.
|
12950120 |
2003 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The M235T polymorphism of the angiotensinogen gene (AGT) is associated with an increased risk of primary hypertension, which may then lead to progressive renal disease.
|
12164881 |
2002 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study provided evidence against an association between angiotensinogen M235T or chymase gene CMA/B polymorphisms and the presence of incipient or overt nephropathy in Caucasian patients with type II diabetes.
|
11096141 |
2000 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this meta-analysis, we attempted to derive pooled estimates for the putative associations between various cardiovascular-renal disorders and the M235T polymorphism of the angiotensinogen gene.
|
10100088 |
1999 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that among males (but not females) the T allele of the M235T polymorphism was transmitted preferentially to those with nephropathy compared with IDDM patients without nephropathy (P=.05).
|
9461232 |
1998 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study examined the association between the development of nephropathy in non-insulin-dependent diabetes mellitus (NIDDM) patients and M235T polymorphism in the angiotensinogen gene.
|
9535411 |
1998 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the angiotensinogen polymorphism M235T might influence susceptibility to nephropathy in insulin-dependent diabetes, but its effect, if any, is rather small and independent of hypertension.
|
8621207 |
1996 |
|
rs11122576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Minor alleles of AGT SNPs rs1926723 and rs11122576 were associated with more frequent history of renal disease (P0.04) and type-2 diabetes (P0.02), higher body mass index (P0.02) and greater mortality (P0.007).
|
22739771 |
2013 |
|
rs11568054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
AGT rs11568054 minor allele carriers had more frequent history of renal disease (P=0.04) and higher plasma creatinine (P=0.033).
|
22739771 |
2013 |
|
rs1926723
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Minor alleles of AGT SNPs rs1926723 and rs11122576 were associated with more frequent history of renal disease (P0.04) and type-2 diabetes (P0.02), higher body mass index (P0.02) and greater mortality (P0.007).
|
22739771 |
2013 |