|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population
|
31128065 |
2019 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the recessive model of inheritance, we found borderline associations between CLL risk and C/C genotype of rs1642785 (p=0.048); G/G genotype of rs2909430 (in men only; p=0.036) and Pro72Pro genotype of rs1042522 (in men only; p=0.045).
|
28364582 |
2017 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although the p53 R72P SNPs and MDM2 SNP309 did not associate with any of the parameters studied, the BAX G125A SNPs was associated with a more advanced Binet stage at diagnosis, supporting a potential role for this variant in CLL disease progression.
|
17981213 |
2007 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population
|
31128065 |
2019 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population
|
31128065 |
2019 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Although the p53 R72P SNPs and MDM2 SNP309 did not associate with any of the parameters studied, the BAX G125A SNPs was associated with a more advanced Binet stage at diagnosis, supporting a potential role for this variant in CLL disease progression.
|
17981213 |
2007 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Although the p53 R72P SNPs and MDM2 SNP309 did not associate with any of the parameters studied, the BAX G125A SNPs was associated with a more advanced Binet stage at diagnosis, supporting a potential role for this variant in CLL disease progression.
|
17981213 |
2007 |
|
rs1642785
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the recessive model of inheritance, we found borderline associations between CLL risk and C/C genotype of rs1642785 (p=0.048); G/G genotype of rs2909430 (in men only; p=0.036) and Pro72Pro genotype of rs1042522 (in men only; p=0.045).
|
28364582 |
2017 |
|
rs1800372
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest that some TP53 variants may affect the risk of CLL. rs1800372 polymorphism might be the marker of unfavorable prognosis of the disease.
|
28364582 |
2017 |
|
rs2909430
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the recessive model of inheritance, we found borderline associations between CLL risk and C/C genotype of rs1642785 (p=0.048); G/G genotype of rs2909430 (in men only; p=0.036) and Pro72Pro genotype of rs1042522 (in men only; p=0.045).
|
28364582 |
2017 |
|
rs879253942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified the L265P hotspot mutation in 86% (n=67/78) of our LPL and 2% (n=12/767) of our CLL cohort.
|
27840426 |
2017 |
|
rs28934578
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we used a CLL mouse model (Eμ-TCL1) harboring one of the most common TP53 hot-spot mutations observed in CLL (p53(R172H), corresponding to p53(R175H) in humans) to evaluate its impact on disease progression, survival, response to therapy and loss of the remaining wild-type Trp53 allele following ibrutinib treatment.
|
27284738 |
2016 |
|
rs1064796681
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the p53 R72P SNPs and MDM2 SNP309 did not associate with any of the parameters studied, the BAX G125A SNPs was associated with a more advanced Binet stage at diagnosis, supporting a potential role for this variant in CLL disease progression.
|
17981213 |
2007 |
|
rs876660821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DNA sequencing of p53 exons 5 to 9 revealed a codon 179 His to Gln change in one of the ELISA-positive, progressive B-CLL but failed to reveal any mutations in 4 other ELISA-positive, progressive B-CLL.
|
8056442 |
1994 |