|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the studied Egyptian population, it can be concluded that the C allele, CC, and CT genotypes of <i>ARID5B</i> rs10821936 and the CA haplotype may be a susceptibility risk factor for pediatric and adult ALL.
|
31424309 |
2019 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Similar results were observed when restricting our analyses to those with the B-ALL subtype: ARID5B rs10821936 RR = 2.22, 95% CI = 1.63-3.02, p = 9.63×10-8 and ARID5B rs7089424 RR = 2.13, 95% CI = 1.57-2.88, p = 2.81×10-7.
|
28817678 |
2017 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between ALL and rs10821936 and rs7089424 ARID5B SNPs were found (OR = 1.9, 95% CI (1.5-2.4) and OR = 2.0, 95% CI (1.6-2.5), respectively).
|
28476190 |
2016 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings provide the rst evidence that SNPs ARID5B- rs10821936 and IKZF1-rs4132601 are associated with decreased B-lineage ALL susceptibility in Indian children.
|
27644650 |
2016 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNPs (IKZF1 rs11978267, ARID5B rs10821936 and rs10994982, CEBPE rs2239633) were genotyped in 265 cases [169 acute lymphoblastic leukemia (ALL) and 96 acute myeloid leukaemia (AML)] and 505 controls by Taqman allelic discrimination assay.
|
24564228 |
2014 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that rs10821936 polymorphism in ARID5B gene was associated with increased risk for ALL (P < 0.0001; OR = 1.27; 95%CI, 1.17-1.37).
|
23975371 |
2014 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For ARID5B (rs10821936), homozygosity for the variant allele increased risk for the ALL/MLL- subgroup only (OR = 7.2, 95% CI = 2.5-20.6).
|
22422485 |
2013 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, ARID5B rs10821936 could serve as a potential biomarker for assessing the risk of childhood ALL in Chinese children.
|
23608171 |
2013 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among 49 ARID5B SNPs interrogated, 10 were significantly associated with ALL susceptibility in both whites and Hispanics (P < .05), with risk alleles consistently more frequent in Hispanics than in whites. rs10821936 exhibited the most significant association in both races (P = 8.4 × 10(-20) in whites; P = 1 × 10(-6) in Hispanics), and genotype at this SNP was highly correlated with local Native American genetic ancestry (P = 1.8 × 10(-8)).
|
22291082 |
2012 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In an attempt to replicate the findings of 2 recent genome-wide association studies in a French-Canadian cohort, we confirmed the association of 5 SNPs [rs7073837 (P=4.2 x 10(-4)), rs10994982 (P=3.8 x 10(-4)), rs10740055 (P=1.6 x 10(-5)), rs10821936 (P=1.7 x 10(-7)) and rs7089424 (P=3.6 x 10(-7))] in the ARID5B gene with childhood acute lymphoblastic leukemia.
|
20460642 |
2010 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two SNPs in ARID5B not only differed between ALL and non-ALL groups (rs10821936, P = 1.4 x 10(-15), odds ratio (OR) = 1.91; rs10994982, P = 5.7 x 10(-9), OR = 1.62) but also distinguished B-hyperdiploid ALL from other subtypes (rs10821936, P = 1.62 x 10(-5), OR = 2.17; rs10994982, P = 0.003, OR 1.72).
|
19684603 |
2009 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
ARID5B rs7089424 and rs10994982 might serve as genetic susceptibility markers for B-ALL in Chinese pediatric population.
|
31274788 |
2019 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The CAG haplotype (rs10821936, rs10994982, rs7089424) was strongly associated with ALL risk in our population (p < 0.00001).
|
31227872 |
2019 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The current case-control study evaluated variants in ARID5B (rs7089424, rs10821936), IKZF1 (rs4132601) and CEBPE (rs2239633) genes, which appear most significantly associated with risk of developing childhood B-lineage ALL.
|
27644650 |
2016 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our results, which are consistent with findings in European populations, show that 3 SNPs, i.e., rs4132601 (P = .00116, odds ratio [OR] = 2.78, 95% confidence interval [CI] = [1.42, 5.87]), rs7089424 (P = .0022, OR = 0.49, 95% CI = [0.31, 0.79]), and rs2239633 (P = .0010, OR = 0.47, 95% CI = [0.29, 0.75]) are significantly associated with a higher risk of developing pediatric ALL (P < .05).
|
27184773 |
2016 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The distribution of genotype rs7073837 in ARID5B significantly differed between ALL and controls (P=0.046), while those of IKZF1 (rs6964823, rs4132601, and rs6944602) and ARID5B (rs10740055 and rs7089424) did not.
|
24200646 |
2014 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
These results indicate that SNPs rs10994982 and rs7089424 are indeed significantly associated with increased risk of childhood ALL.
|
25124600 |
2014 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In an attempt to replicate the findings of 2 recent genome-wide association studies in a French-Canadian cohort, we confirmed the association of 5 SNPs [rs7073837 (P=4.2 x 10(-4)), rs10994982 (P=3.8 x 10(-4)), rs10740055 (P=1.6 x 10(-5)), rs10821936 (P=1.7 x 10(-7)) and rs7089424 (P=3.6 x 10(-7))] in the ARID5B gene with childhood acute lymphoblastic leukemia.
|
20460642 |
2010 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To explore the impact of these variants on ALL risk in the Thai population, we genotyped 190 cases of ALL and 182 controls for SNPs rs4132601 (7p12.2), rs3731217 (9p21.3), rs7089424 and rs10821938 (10q21.2), and rs2239633 (14q11.2).
|
20919861 |
2010 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 x 10(-19)), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6.69 x 10(-19)) and 14q11.2 (CEBPE, rs2239633, OR = 1.34, P = 2.88 x 10(-7)).
|
19684604 |
2009 |
|
rs10994982
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The CAG haplotype (rs10821936, rs10994982, rs7089424) was strongly associated with ALL risk in our population (p < 0.00001).
|
31227872 |
2019 |
|
rs10994982
|
|
|
0.070 |
GeneticVariation |
BEFREE |
ARID5B rs7089424 and rs10994982 might serve as genetic susceptibility markers for B-ALL in Chinese pediatric population.
|
31274788 |
2019 |
|
rs10994982
|
|
|
0.070 |
GeneticVariation |
BEFREE |
However, the SNPs of <i>ARID5B</i> rs10821936 and rs10994982</span> were not found to be strongly associated with ALL outcomes.
|
31424309 |
2019 |
|
rs10994982
|
|
|
0.070 |
GeneticVariation |
BEFREE |
These results indicate that SNPs rs10994982 and rs7089424 are indeed significantly associat</span>ed with increased risk of childhood ALL.
|
25124600 |
2014 |
|
rs10994982
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The SNPs (IKZF1 rs11978267, ARID5B rs10821936 and rs10994982, CEBPE rs2239633) were genotyped in 265 cases [169 acute lymphoblastic leukemia (ALL) and 96 acute myeloid leukaemia (AML)] and 505 controls by Taqman allelic discrimination assay.
|
24564228 |
2014 |