DisGeNET - a database of gene-disease associations

Leukemia, Myelocytic, Acute, C0023467

Variant: rs121913487 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs121913487

FLT3

0.800

CausalMutation

CLINVAR

FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression.

15374878

2005

dbSNP:

rs121913487

FLT3

0.800

CausalMutation

CLINVAR

Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.

15256420

2004

dbSNP:

rs121913487

FLT3

0.800

CausalMutation

CLINVAR

Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.

15256420

2004

dbSNP:

rs121913487

FLT3

0.800

CausalMutation

CLINVAR

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.

11290608

2001

dbSNP:

rs121913487

FLT3

0.800

CausalMutation

CLINVAR

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.

11290608

2001

dbSNP:

rs121913487

FLT3

0.800

GeneticVariation

UNIPROT