Gene: TP53 ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11540652
rs11540652
TP53
0.710 GeneticVariation BEFREE Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells. 30948782

2019
dbSNP: rs886039484
rs886039484
TP53
0.710 GeneticVariation BEFREE We suggest that SNPs in the P53 pathway, especially the P21 ser31arg polymorphism and combined polymorphisms especially the P21/ MDM2 might be genetic susceptibility factors in the pathogenesis of AML. 23167335

2012
dbSNP: rs121912651
rs121912651
TP53
0.710 GeneticVariation BEFREE We have recently established the MV4-11 acute myelogenous leukemia (AML) subline, designated as MV4-11 TP53 R248W, which possesses a missense mutation (CGG→TGG; R248W) in the TP53 gene, leading to inactivation of this transcription factor. 21550660

2011
dbSNP: rs1042522
rs1042522
TP53
0.020 GeneticVariation BEFREE In conclusion, the results suggest that there is no association between TP53 Arg72Pro polymorphism and the risk of leukemia, but the CC genotype may increase the risk of ALL TP53 Arg72Pro polymorphism CC genotype may increase the risk of ALL but is not associated with AML. 27053289

2016
dbSNP: rs1131691014
rs1131691014
TP53
0.020 GeneticVariation BEFREE In conclusion, the results suggest that there is no association between TP53 Arg72Pro polymorphism and the risk of leukemia, but the CC genotype may increase the risk of ALL TP53 Arg72Pro polymorphism CC genotype may increase the risk of ALL but is not associated with AML. 27053289

2016
dbSNP: rs878854066
rs878854066
TP53
0.020 GeneticVariation BEFREE In conclusion, the results suggest that there is no association between TP53 Arg72Pro polymorphism and the risk of leukemia, but the CC genotype may increase the risk of ALL TP53 Arg72Pro polymorphism CC genotype may increase the risk of ALL but is not associated with AML. 27053289

2016
dbSNP: rs1042522
rs1042522
TP53
0.020 GeneticVariation BEFREE There is no significant association of P53 arg72pro polymorphism on the risk of AML. 23167335

2012
dbSNP: rs1131691014
rs1131691014
TP53
0.020 GeneticVariation BEFREE There is no significant association of P53 arg72pro polymorphism on the risk of AML. 23167335

2012
dbSNP: rs878854066
rs878854066
TP53
0.020 GeneticVariation BEFREE There is no significant association of P53 arg72pro polymorphism on the risk of AML. 23167335

2012
dbSNP: rs1057520001
rs1057520001
TP53
0.010 GeneticVariation BEFREE We suggest that SNPs in the P53 pathway, especially the P21 ser31arg polymorphism and combined polymorphisms especially the P21/ MDM2 might be genetic susceptibility factors in the pathogenesis of AML. 23167335

2012
dbSNP: rs587782529
rs587782529
TP53
0.010 GeneticVariation BEFREE The novel somatic mutation, R337G (16900C>G), was discovered in myelodysplastic syndrome with transformation to acute myeloblastic leukemia, developing as the third primary in the LFS child. 19714490

2009
dbSNP: rs1057519975
rs1057519975
TP53
0.010 GeneticVariation BEFREE We previously identified a case of human acute myelogenous leukemia (AML) in which both alleles of the p53 gene had undergone independent missense mutations (at codons 135 cys to ser and 246 met to val). 1918170

1991
dbSNP: rs483352695
rs483352695
TP53
0.010 GeneticVariation BEFREE We previously identified a case of human acute myelogenous leukemia (AML) in which both alleles of the p53 gene had undergone independent missense mutations (at codons 135 cys to ser and 246 met to val). 1918170

1991