|
rs1800469
|
|
|
0.040 |
GeneticVariation |
BEFREE |
No associations with COPD were identified for other polymorphisms evaluated in the present study including rs1800469 (T allele compared with C allele, OR =0.89, 95% CI: 0.77-1.02, <i>P</i>=0.099), rs2241712 (A allele compared with G allele, OR =1.03, 95% CI: 0.89-1.20, <i>P</i>=0.666), rs6957 (A allele compared with G allele, OR =1.14, 95% CI: 0.95-1.36, <i>P</i>=0.160), and rs2241718 (C allele compared with T allele, OR =0.95, 95% CI: 0.79-1.14, <i>P</i>=0.571).
|
28784933 |
2017 |
|
rs1800469
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The SNP rs1800469 is reported to be associated with chronic obstructive pulmonary disease and lung cancer in cigarette smokers.
|
23094028 |
2012 |
|
rs1800469
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The results showed that there was no significant association between an increased risk of COPD in carriers of the T allele (TT+TC) versus the CC genotype in rs1800469 and rs1982073.
|
21556788 |
2011 |
|
rs1800469
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Among smokers in the COPD cases and control subjects, two SNPs in the promoter region of TGFB1 (rs2241712 and rs1800469) and one SNP in exon 1 of TGFB1 (rs1982073) were significantly associated with COPD (P</=0.02 in all cases).
|
15175276 |
2004 |
|
rs1982073
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis showed that the C allele of rs1982073 was protective against COPD in Caucasians but not in Asians, whereas there was no association of rs1800469, rs2241712, rs6957, and rs2241718 with COPD.
|
28784933 |
2017 |
|
rs2241718
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis showed that the C allele of rs1982073 was protective against COPD in Caucasians but not in Asians, whereas there was no association of rs1800469, rs2241712, rs6957, and rs2241718 with COPD.
|
28784933 |
2017 |
|
rs1800470
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The FPRP test results were as follows: 1) when the prior probability was 0.001 and the OR was 1.5, ADAM33 rs612709, CHRNA3/5 rs1051730, CHRNA3/5 rs8034191, CHRNA3/5 rs16969968, and TGFB1 rs1800470 were truly associated with COPD risk (FPRP < 0.2); 2) when the prior probability was 0.000001 and the OR was 1.5, all the variants except TGFB1 rs1800470 remained noteworthy; and 3) when the probability was 0.000001 and the OR was 1.2, ADAM33 rs612709 and CHRNA3/5 rs1051730 remained true positives.
|
27323020 |
2016 |
|
rs2241718
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).
|
23267696 |
2012 |
|
rs1982073
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The results showed that there was no significant association between an increased risk of COPD in carriers of the T allele (TT+TC) versus the CC genotype in rs1800469 and rs1982073.
|
21556788 |
2011 |
|
rs2241718
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We genotyped 160 cases and 177 control subjects in a local hospital using the Mass-Array(TM) Technology Platform and then tested the association of four SNPs in TGF-β(1) (rs6957, rs1800469, rs2241712, and rs2241718) with COPD.
|
21556788 |
2011 |
|
rs1800470
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Two SNPs in TGFB1 (C to T substitution at nucleotide -509 and substitution of leucine 10 with proline (Leu10Pro)), Leu50Val in SFTPA1 and Ala160Thr in SFTPD showed evidence suggestive of association with FEV(1)/IVC in subjects with GOLD stage >or=2 COPD.
|
19797132 |
2010 |
|
rs1800470
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Of these variants, four were significantly associated with COPD susceptibility in random effects meta-analysis, the GSTM1 null variant (OR 1.45, CI 1.09-1.92), rs1800470 in TGFB1 (0.73, CI 0.64-0.83), rs1800629 in TNF (OR 1.19, CI 1.01-1.40) and rs1799896 in SOD3 (OR 1.97, CI 1.24-3.13).
|
19933216 |
2010 |
|
rs1982073
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Among smokers in the COPD cases and control subjects, two SNPs in the promoter region of TGFB1 (rs2241712 and rs1800469) and one SNP in exon 1 of TGFB1 (rs1982073) were significantly associated with COPD (P</=0.02 in all cases).
|
15175276 |
2004 |
|
rs6957
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No associations with COPD were identified for other polymorphisms evaluated in the present study including rs1800469 (T allele compared with C allele, OR =0.89, 95% CI: 0.77-1.02, <i>P</i>=0.099), rs2241712 (A allele compared with G allele, OR =1.03, 95% CI: 0.89-1.20, <i>P</i>=0.666), rs6957 (A allele compared with G allele, OR =1.14, 95% CI: 0.95-1.36, <i>P</i>=0.160), and rs2241718 (C allele compared with T allele, OR =0.95, 95% CI: 0.79-1.14, <i>P</i>=0.571).
|
28784933 |
2017 |
|
rs6957
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).
|
23267696 |
2012 |