|
rs13181
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional polymorphisms in XPD (Asp312Asn, rs1799793 and Lys751Gln, rs1052559), a protein required for nucleotide excision repair and with roles in p53-mediated apoptosis, were modestly associated with G:C-->T:A mutations in TP53 in lung tumors [Asp/Asn312 + Asn/Asn312 and/or Lys/Gln751 + Gln/Gln751 versus Asp/Asp312 + Lys/Lys751; odds ratio (OR) 2.73, 95% confidence interval (CI) 0.98-7.61], consistent with the role of this protein in repair of bulky carcinogen-DNA adducts.
|
15564288 |
2005 |
|
rs1444669684
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Conditional deletion of Foxm1 from Kras(G12D)-expressing respiratory epithelium prevented the initiation of lung tumors in vivo.
|
24213573 |
2014 |
|
rs1444669684
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Coactivation of BRAF(V600E) and KRAS(G12D) markedly reduced lung tumor numbers and overall tumor burden compared with activation of BRAF(V600E) alone.
|
26028035 |
2016 |
|
rs1458974438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In mice, Lkb1 deletion and activation of Kras(G12D) results in lung tumors with a high penetrance of lymph node and distant metastases.
|
20541700 |
2010 |
|
rs16906252
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele was selectively methylated in primary lung tumors and cell lines heterozygous for rs16906252.
|
21355081 |
2011 |
|
rs1799793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional polymorphisms in XPD (Asp312Asn, rs1799793 and Lys751Gln, rs1052559), a protein required for nucleotide excision repair and with roles in p53-mediated apoptosis, were modestly associated with G:C-->T:A mutations in TP53 in lung tumors [Asp/Asn312 + Asn/Asn312 and/or Lys/Gln751 + Gln/Gln751 versus Asp/Asp312 + Lys/Lys751; odds ratio (OR) 2.73, 95% confidence interval (CI) 0.98-7.61], consistent with the role of this protein in repair of bulky carcinogen-DNA adducts.
|
15564288 |
2005 |
|
rs199976573
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, Klf5 is not required for lung tumor formation in an inducible oncogenic K-Ras(G12D) mouse model of lung tumorigenesis, and non-small cell lung cancer patients expressing high levels of KLF5 (21/258) have a significantly better disease-specific survival than those with intermediate to no KLF5 expression.
|
20639455 |
2010 |
|
rs372043866
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Interestingly, acute loss of Erbb3 suppressed further growth of established EGFR(L858R)-mediated lung tumors.
|
25596284 |
2015 |
|
rs372043866
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Similarly, deficiency of Puma impeded the regression of EGFR(L858R)-driven mouse lung tumors upon inactivation of the EGFR-activating mutant.
|
23532334 |
2013 |
|
rs3743073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that four of the variants (rs3829787, rs3841324, rs588765 and rs3743073) were associated with differential levels of genetic alterations measured as the levels of hydrophobic DNA adducts in the adjacent histologically normal tissue of the lung cancer patients and as TP53 mutations in their lung tumors.
|
23011884 |
2013 |
|
rs587782329
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Lung tumors of 50 uranium miners in Germany were screened by restriction fragment length analysis for the putative hotspot mutation at codon 249 (Arg-->Met) previously detected in a significant fraction of miners from the Colorado Plateau, USA.
|
9067550 |
1997 |
|
rs588765
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that four of the variants (rs3829787, rs3841324, rs588765 and rs3743073) were associated with differential levels of genetic alterations measured as the levels of hydrophobic DNA adducts in the adjacent histologically normal tissue of the lung cancer patients and as TP53 mutations in their lung tumors.
|
23011884 |
2013 |
|
rs6808523
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, expression quantitative trait loci (eQTL) analysis revealed that these two genes were differently expressed between lung tumor and adjacent normal tissues in the database of The Cancer Genome Atlas (TCGA) (P=0.009 for rs6808523).
|
27179949 |
2016 |
|
rs752021744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In mice, Lkb1 deletion and activation of Kras(G12D) results in lung tumors with a high penetrance of lymph node and distant metastases.
|
20541700 |
2010 |
|
rs759404153
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, acute loss of Erbb3 suppressed further growth of established EGFR(L858R)-mediated lung tumors.
|
25596284 |
2015 |
|
rs762846821
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Conversely, in lung tumour cell lines expressing Kras(G12D) and lacking p53, p53 restoration led to NF-kappaB inhibition.
|
19847165 |
2009 |
|
rs762846821
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRAS(G12D)-driven lung tumors.
|
23959381 |
2013 |
|
rs762846821
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We crossed IL-6(-/-) mice with Kras(G12D) mutant mice, which develop lung tumors after activation of mutant Kras(G12D), to investigate whether IL-6 inhibition contributes to tumor progression and survival time in vivo.
|
24260500 |
2013 |
|
rs772399455
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conditional deletion of Foxm1 from Kras(G12D)-expressing respiratory epithelium prevented the initiation of lung tumors in vivo.
|
24213573 |
2014 |
|
rs775514340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, a more rigorous test of the requirement for Notch signaling in lung oncogenesis, crossing the LSL-KRAS(G12D) mouse model with a transgenic with a similarly inducible global dominant-negative suppressor of Notch activity, LSL-DNMAML (dominant-negative mastermind-like), reveals no evidence of Notch pathway requirement for lung tumor initiation or growth in vivo.
|
21994468 |
2011 |
|
rs8021944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For SNPs rs8021944, rs1256061 and rs10146204, ERβ expression was higher according to the rank sum test in lung tumors from patients with at least one minor allele.
|
23619141 |
2013 |
|
rs947996134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutant Ki-ras(G12C) expression was sufficient for initial lung tumor transformation, required for maintenance of tumor phenotype, and induced transformation of lung epithelial cells by the activation of multiple effector pathways.
|
16051643 |
2005 |