|
rs2004640
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although we could not demonstrate susceptibility toward lupus in the presence of IRF5 rs2004640 (G/T) polymorphism, further exploration of the genetic variability of IRF5 may help uncover its pathogenic role in Indian SLE patients.
|
30168487 |
2018 |
|
rs292001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
C1q rs292001 polymorphism and C1q antibodies in juvenile lupus and their relation to lupus nephritis.
|
26095468 |
2015 |
|
rs11889341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consistent with expression quantitative trait locus (eQTL) analysis, the l</span>upus risk allele of rs11889341 decreased the activity of this putative repressor.
|
29912393 |
2018 |
|
rs13023380
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DNA carrying the intronic risk allele rs13023380 showed reduced binding efficiency to a cellular protein complex including nucleolin and lupus autoantigen Ku70/80, and showed reduced transcriptional activity in vivo.
|
23441136 |
2013 |
|
rs370504038
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five heterozygous mutations were detected at the Y305C polymorphism in European lupus cases but none were observed in European controls.
|
21270825 |
2011 |
|
rs7574865
|
|
|
0.020 |
GeneticVariation |
BEFREE |
For the first time, we have shown that the polymorphisms located in the <i>STAT4</i> (rs7574865), but not in the <i>ITGAM</i> (rs1143679) nor the <i>TNXB</i> (rs1150754) genes, might be associated with the development of DLE within the Polish population.
|
28670251 |
2017 |
|
rs1143679
|
|
|
0.020 |
GeneticVariation |
BEFREE |
For the first time, we have shown that the polymorphisms located in the <i>STAT4</i> (rs7574865), but not in the <i>ITGAM</i> (rs1143679) nor the <i>TNXB</i> (rs1150754) genes, might be associated with the development of DLE within the Polish population.
|
28670251 |
2017 |
|
rs1150754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the first time, we have shown that the polymorphisms located in the <i>STAT4</i> (rs7574865), but not in the <i>ITGAM</i> (rs1143679) nor the <i>TNXB</i> (rs1150754) genes, might be associated with the development of DLE within the Polish population.
|
28670251 |
2017 |
|
rs3093061
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032).
|
29556849 |
2018 |
|
rs1130864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032).
|
29556849 |
2018 |
|
rs1205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032).
|
29556849 |
2018 |
|
rs1270942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively).
|
21952918 |
2012 |
|
rs3131379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively).
|
21952918 |
2012 |
|
rs2070197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively).
|
21952918 |
2012 |
|
rs1188383936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we evaluated 40 patients with antiphospholipid syndrome and thrombosis, 31 primary and nine secondary to systemic lupus erythemathosus, to estimate the carrier rates of factor V Leiden, 20210A --> G prothrombin variant and 677C --> T in the MTHFR gene.
|
11085290 |
2000 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we evaluated 40 patients with antiphospholipid syndrome and thrombosis, 31 primary and nine secondary to systemic lupus erythemathosus, to estimate the carrier rates of factor V Leiden, 20210A --> G prothrombin variant and 677C --> T in the MTHFR gene.
|
11085290 |
2000 |
|
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interleukin-17A rs2275913, Interleukin-17F rs763780 and rs2397084 gene polymorphisms as possible risk factors in Juvenile lupus and lupus related nephritis.
|
26515887 |
2016 |
|
rs763780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interleukin-17A rs2275913, Interleukin-17F rs763780 and rs2397084 gene polymorphisms as possible risk factors in Juvenile lupus and lupus related nephritis.
|
26515887 |
2016 |
|
rs2397084
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interleukin-17A rs2275913, Interleukin-17F rs763780 and rs2397084 gene polymorphisms as possible risk factors in Juvenile lupus and lupus related nephritis.
|
26515887 |
2016 |
|
rs1518110
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, significant difference in genotype frequency at rs1518110 and rs1518111 were found in patients with and without lupus headache (P=0.025, P=0.038, respectively).
|
29199038 |
2018 |
|
rs1518111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, significant difference in genotype frequency at rs1518110 and rs1518111 were found in patients with and without lupus headache (P=0.025, P=0.038, respectively).
|
29199038 |
2018 |
|
rs12583006
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the presence of the AA genotype of the rs12583006 BAFF gene variant increased susceptibility for both lupus and lupus related plaque formation (ORs [95%CI]: 2.8 [1.1-7.1], and 4.4 [1.3-15.4] in the codominant model, respectively).
|
29859654 |
2018 |
|
rs3810936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings indicate that gene polymorphisms (rs3810936, rs7848647) of TL1A might correlate with lupus.
|
31081141 |
2019 |
|
rs7848647
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings indicate that gene polymorphisms (rs3810936, rs7848647) of TL1A might correlate with lupus.
|
31081141 |
2019 |
|
rs3813946
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphism 1 (rs3813946), located in the 5' untranslated region of the CR2 gene, altered transcriptional activity, suggesting a potential mechanism by which CR2 could contribute to the development of lupus.
|
17360460 |
2007 |