Gene: CR2 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3813946
rs3813946
CR2
0.020 GeneticVariation BEFREE These data confirm the effects of rs3813946 on CR2 transcription, identifying the 5' UTR to be a novel regulatory element for the CR2 gene in which variation may alter gene function and modify the development of lupus. 22673213

2012
dbSNP: rs17615
rs17615
CR2
0.020 GeneticVariation BEFREE A haplotype formed by the minor alleles of three CR2 SNPs (rs1048971, rs17615, rs4308977) showed significant association with decreased risk of SLE (30.4% in cases vs 32.6% in controls, P=0.016, OR=0.90 (0.82-0.98)). 19387458

2009
dbSNP: rs17615
rs17615
CR2
0.020 GeneticVariation BEFREE To explore its role in human disease, we analyzed 1,416 individuals from 258 Caucasian and 142 Chinese lupus simplex families and demonstrated that a common three-single-nucleotide polymorphism CR2 haplotype (rs3813946, rs1048971, rs17615) was associated with lupus susceptibility (P = 0.00001) with a 1.54-fold increased risk for the development of disease. 17360460

2007
dbSNP: rs3813946
rs3813946
CR2
0.020 GeneticVariation BEFREE Single-nucleotide polymorphism 1 (rs3813946), located in the 5' untranslated region of the CR2 gene, altered transcriptional activity, suggesting a potential mechanism by which CR2 could contribute to the development of lupus. 17360460

2007
dbSNP: rs1876453
rs1876453
CR2
0.010 GeneticVariation BEFREE These data suggest that rs1876453 in CR2 has long-range effects on gene regulation that decrease susceptibility to lupus. 25180293

2016
dbSNP: rs4308977
rs4308977
CR2
0.010 GeneticVariation BEFREE A haplotype formed by the minor alleles of three CR2 SNPs (rs1048971, rs17615, rs4308977) showed significant association with decreased risk of SLE (30.4% in cases vs 32.6% in controls, P=0.016, OR=0.90 (0.82-0.98)). 19387458

2009
dbSNP: rs1048971
rs1048971
CR2
0.010 GeneticVariation BEFREE To explore its role in human disease, we analyzed 1,416 individuals from 258 Caucasian and 142 Chinese lupus simplex families and demonstrated that a common three-single-nucleotide polymorphism CR2 haplotype (rs3813946, rs1048971, rs17615) was associated with lupus susceptibility (P = 0.00001) with a 1.54-fold increased risk for the development of disease. 17360460

2007