| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.030 | GeneticVariation | BEFREE | In this review, we have compiled previous studies which have reported the association of <i>CTLA4</i> A49G polymorphism in SLE and its geographical distribution. | 31340988 | 2019 |
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0.030 | GeneticVariation | BEFREE | Cytotoxic T-lymphocyte antigen 4 (CTLA4) is an inhibitory receptor for T cells and this study was carried out to analyze the influence of CTLA4 +49A/G (rs231775) polymorphism on susceptibility to SLE in ethnic Tamils. | 24758310 | 2014 |
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0.030 | GeneticVariation | BEFREE | The results of studies on association between CTLA-4 exon-1 +49A/G (rs231775) polymorphism and susceptibility to systemic lupus erythematosus are controversial. | 22718509 | 2012 |
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|
0.010 | GeneticVariation | BEFREE | Association between 318C/T polymorphism of the CTLA-4 gene and systemic lupus erythematosus in Iranian patients. | 24400885 | 2017 |
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|
0.010 | GeneticVariation | BEFREE | This study was to determine whether -318C/T (rs5742909), -1722T/C (rs733618) and -1661A/G (rs4553808) of Cytotoxic T-lymphocyte antigen-4 (CTLA-4) are associated with systemic lupus erythematosus (SLE). | 23261408 | 2013 |
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0.010 | GeneticVariation | BEFREE | This study was to determine whether -318C/T (rs5742909), -1722T/C (rs733618) and -1661A/G (rs4553808) of Cytotoxic T-lymphocyte antigen-4 (CTLA-4) are associated with systemic lupus erythematosus (SLE). | 23261408 | 2013 |
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|
0.010 | GeneticVariation | BEFREE | But -1722T/C (rs733618) was significantly associated with SLE both in allele {fixed: OR: 0.699, 95% CI: (0.602-0.811), p = 0.000; random: OR: 0.748, 95% CI: (0.565-0.990), p = 0.042} and in genotype {CC/(CT+TT)} meta-analysis {OR: 0.422, 95% CI: (0.297-0.598), p = 0.000}. | 23261408 | 2013 |