rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The TT > A variants and the TNFAIP3 exon 3 coding variant rs2230926 demonstrated significant associations in SLE (P<sub>TT > A</sub> = 8.96 × 10<sup>-12</sup>, odds ratio [OR] = 2.07, 95% confidence interval [CI] = 1.68-2.55).
|
30529365 |
2019 |
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A higher risk to develop SLE was observed for rs2230926 (<i>P</i> = 0.02, OR = 1.92).
|
31534975 |
2019 |
rs2230926
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
|
26663301 |
2016 |
rs2230926
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results of our meta-analysis suggest that TNFAIP3 (rs2230926, rs5029937, rs5029939, and rs3757173) polymorphisms are associated with susceptibility to SLE.
|
27726311 |
2016 |
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Associations of TNFAIP3 rs2230926 (p=1.43 × 10(-3)) and TNIP1 rs10036748 (p=4.33 × 10(-3)) with SLE were replicated in our study.
|
23911423 |
2013 |
rs2230926
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
rs2230926
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs2230926 allele of TNFAIP3 was associated with susceptibility to SLE in males, but after Bonferroni correction there were no significant associations with any of the other four SNPs in IRF5, BLK, TNIP1 and ETS1 genes.
|
24023622 |
2013 |
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Meta-analysis revealed that an association was found between the minor allele of rs2230926 and SLE in all subjects (odds ratio [OR] 1.848, 95% confidence interval [CI] 1.547-2.208, p<1.0×10(-9)).
|
22924496 |
2012 |
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We selected and identified three SNPs of BANK1 associated with SLE (rs17266594, P = 1.949e-10; OR = 1.380; 95% CI: 1.250-1.525; rs10516487, P = 2.642e-13; OR = 1.317; 95% CI: 1.223-1.417; rs3733197, P = 3.452e-06; OR = 1.193; 95% CI: 1.107-1.286); one SNP of TNFAIP3 associated with SLE (rs2230926, P = 1.502e-12; OR = 1.826; 95% CI: 1.545-2.157).
|
21208380 |
2011 |
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed a significant association between rs2230926 and an increased risk of SLE and RA in the Japanese population (for SLE, odds ratio [OR] 1.92, 95% confidence interval [95% CI] 1.53-2.41, P = 1.9 x 10(-8); for RA, OR 1.35, 95% CI 1.18-1.56, P = 2.6 x 10(-5)).
|
20112363 |
2010 |
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There are two nonsynonymous coding polymorphisms in the deubiquitinating (DUB) domain of TNFAIP3: F127C, which is in high-linkage disequilibrium with reported SLE-risk variants, and A125V, which has not been previously studied.
|
20483768 |
2010 |
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings suggest that SNP rs2230926 in the TNFAIP3 might be a common genetic factor for SLE within different populations in terms of Chinese Han and European population.
|
19774492 |
2010 |
rs2230926
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
rs2230926
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic lupus erythematosus (SLE) among individuals of European ancestry.
|
19165919 |
2008 |
rs5029939
|
|
C |
0.850 |
GeneticVariation |
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
rs5029939
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The results of our meta-analysis suggest that TNFAIP3 (rs2230926, rs5029937, rs5029939, and rs3757173) polymorphisms are associated with susceptibility to SLE.
|
27726311 |
2016 |
rs5029939
|
|
|
0.850 |
GeneticVariation |
BEFREE |
To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility.
|
26092158 |
2015 |
rs5029939
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Single-marker analysis validated the association of BLK rs2736340 (P=4.25×10(-6)) as well as TNFSF4 rs2205960 (P=2.82×10(-5)) and TNFAIP3 rs5029939 (P=1.92×10(-3)) with SLE susceptibility in Chinese.
|
21905002 |
2012 |
rs5029939
|
|
|
0.850 |
GeneticVariation |
BEFREE |
In addition, a significant association was found between the minor allele of the rs5029939 polymorphism and the risk of developing SLE in all study subjects and Europeans (OR 1.804, 95% CI 1.255-2.592, p=0.001; OR 2.145, 95% CI 1.731-2.658, p<1.0×10(-9)).
|
22924496 |
2012 |
rs5029939
|
|
|
0.850 |
GeneticVariation |
BEFREE |
We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29).
|
19165918 |
2008 |
rs5029939
|
|
|
0.850 |
GeneticVariation |
GWASCAT |
We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29).
|
19165918 |
2008 |
rs5029939
|
|
|
0.850 |
GeneticVariation |
GWASDB |
We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29).
|
19165918 |
2008 |