|
rs3024493
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Significant interactions were observed between <i>CD40</i> variant rs48100485 and VCA IgG levels and <i>IL10</i> variant rs3024493 and VCA IgA levels in transitioning to SLE.
|
31217170 |
2019 |
|
rs3024493
|
|
|
0.720 |
GeneticVariation |
BEFREE |
SNP imputation conducted in EA dataset identified three additional SLE-associated SNPs tagged by rs3024505 (rs3122605, rs3024493 and rs3024495 located at 9.2 kb upstream, intron 3 and 4 of IL10, respectively), and SLE-risk alleles of these SNPs were dose-dependently associated with elevated levels of IL10 mRNA in PBMCs and circulating IL-10 protein in SLE patients and controls.
|
24130510 |
2013 |
|
rs1800896
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Interleukin 10 gene promoter polymorphisms (rs1800896, rs1800871 and rs1800872) and haplotypes are associated with the activity of systemic lupus erythematosus and IL10 levels in an Iranian population.
|
30430731 |
2019 |
|
rs1800896
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In addition, we found IL-10 rs1800896 GG homozygote might be associated with increased susceptibility to SLE (GG vs AA, P = 4.65 × 10<sup>-3</sup>, OR 1.539, 95% CI 1.142-2.072).
|
30171347 |
2018 |
|
rs1800896
|
|
|
0.030 |
GeneticVariation |
BEFREE |
There was no association between rs1800896 and SLE, although a tendency for genetic predisposition to SLE was observed for the IL10 -1082 GG genotype under the recessive genetic model (OR = 1.454).
|
29298134 |
2018 |
|
rs1800871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interleukin 10 gene promoter polymorphisms (rs1800896, rs1800871 and rs1800872) and haplotypes are associated with the activity of systemic lupus erythematosus and IL10 levels in an Iranian population.
|
30430731 |
2019 |
|
rs1800872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interleukin 10 gene promoter polymorphisms (rs1800896, rs1800871 and rs1800872) and haplotypes are associated with the activity of systemic lupus erythematosus and IL10 levels in an Iranian population.
|
30430731 |
2019 |
|
rs1518110
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, significant difference in genotype frequency at rs1518110 and rs1518111 were found in patients with and without lupus headache (P=0.025, P=0.038, respectively).
|
29199038 |
2018 |
|
rs1518111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, significant difference in genotype frequency at rs1518110 and rs1518111 were found in patients with and without lupus headache (P=0.025, P=0.038, respectively).
|
29199038 |
2018 |
|
rs3024498
|
|
|
0.010 |
GeneticVariation |
BEFREE |
And, there was significant difference in allele frequency at rs3024498 between SLE patients with and without anti-double-stranded DNA (P=0.032).
|
29199038 |
2018 |
|
rs3024495
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP imputation conducted in EA dataset identified three additional SLE-associated SNPs tagged by rs3024505 (rs3122605, rs3024493 and rs3024495 located at 9.2 kb upstream, intron 3 and 4 of IL10, respectively), and SLE-risk alleles of these SNPs were dose-dependently associated with elevated levels of IL10 mRNA in PBMCs and circulating IL-10 protein in SLE patients and controls.
|
24130510 |
2013 |