|
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The TT > A variants and the TNFAIP3 exon 3 coding variant rs2230926 demonstrated significant associations in SLE (P<sub>TT > A</sub> = 8.96 × 10<sup>-12</sup>, odds ratio [OR] = 2.07, 95% confidence interval [CI] = 1.68-2.55).
|
30529365 |
2019 |
|
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A higher risk to develop SLE was observed for rs2230926 (<i>P</i> = 0.02, OR = 1.92).
|
31534975 |
2019 |
|
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results of our meta-analysis suggest that TNFAIP3 (rs2230926, rs5029937, rs5029939, and rs3757173) polymorphisms are associated with susceptibility to SLE.
|
27726311 |
2016 |
|
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs2230926 allele of TNFAIP3 was associated with susceptibility to SLE in males, but after Bonferroni correction there were no significant associations with any of the other four SNPs in IRF5, BLK, TNIP1 and ETS1 genes.
|
24023622 |
2013 |
|
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Associations of TNFAIP3 rs2230926 (p=1.43 × 10(-3)) and TNIP1 rs10036748 (p=4.33 × 10(-3)) with SLE were replicated in our study.
|
23911423 |
2013 |
|
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Meta-analysis revealed that an association was found between the minor allele of rs2230926 and SLE in all subjects (odds ratio [OR] 1.848, 95% confidence interval [CI] 1.547-2.208, p<1.0×10(-9)).
|
22924496 |
2012 |
|
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We selected and identified three SNPs of BANK1 associated with SLE (rs17266594, P = 1.949e-10; OR = 1.380; 95% CI: 1.250-1.525; rs10516487, P = 2.642e-13; OR = 1.317; 95% CI: 1.223-1.417; rs3733197, P = 3.452e-06; OR = 1.193; 95% CI: 1.107-1.286); one SNP of TNFAIP3 associated with SLE (rs2230926, P = 1.502e-12; OR = 1.826; 95% CI: 1.545-2.157).
|
21208380 |
2011 |
|
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed a significant association between rs2230926 and an increased risk of SLE and RA in the Japanese population (for SLE, odds ratio [OR] 1.92, 95% confidence interval [95% CI] 1.53-2.41, P = 1.9 x 10(-8); for RA, OR 1.35, 95% CI 1.18-1.56, P = 2.6 x 10(-5)).
|
20112363 |
2010 |
|
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings suggest that SNP rs2230926 in the TNFAIP3 might be a common genetic factor for SLE within different populations in terms of Chinese Han and European population.
|
19774492 |
2010 |
|
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There are two nonsynonymous coding polymorphisms in the deubiquitinating (DUB) domain of TNFAIP3: F127C, which is in high-linkage disequilibrium with reported SLE-risk variants, and A125V, which has not been previously studied.
|
20483768 |
2010 |
|
rs2230926
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic lupus erythematosus (SLE) among individuals of European ancestry.
|
19165919 |
2008 |
|
rs5029939
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The results of our meta-analysis suggest that TNFAIP3 (rs2230926, rs5029937, rs5029939, and rs3757173) polymorphisms are associated with susceptibility to SLE.
|
27726311 |
2016 |
|
rs5029939
|
|
|
0.850 |
GeneticVariation |
BEFREE |
To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility.
|
26092158 |
2015 |
|
rs5029939
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Single-marker analysis validated the association of BLK rs2736340 (P=4.25×10(-6)) as well as TNFSF4 rs2205960 (P=2.82×10(-5)) and TNFAIP3 rs5029939 (P=1.92×10(-3)) with SLE susceptibility in Chinese.
|
21905002 |
2012 |
|
rs5029939
|
|
|
0.850 |
GeneticVariation |
BEFREE |
In addition, a significant association was found between the minor allele of the rs5029939 polymorphism and the risk of developing SLE in all study subjects and Europeans (OR 1.804, 95% CI 1.255-2.592, p=0.001; OR 2.145, 95% CI 1.731-2.658, p<1.0×10(-9)).
|
22924496 |
2012 |
|
rs5029939
|
|
|
0.850 |
GeneticVariation |
BEFREE |
We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29).
|
19165918 |
2008 |
|
rs3757173
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The results of our meta-analysis suggest that TNFAIP3 (rs2230926, rs5029937, rs5029939, and rs3757173) polymorphisms are associated with susceptibility to SLE.
|
27726311 |
2016 |
|
rs3757173
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Furthermore, an association was found between the minor allele of rs3757173 and SLE in all study subjects (OR 1.540, 95% CI 1.017-2.331, p=0.041).
|
22924496 |
2012 |
|
rs5029937
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The results of our meta-analysis suggest that TNFAIP3 (rs2230926, rs5029937, rs5029939, and rs3757173) polymorphisms are associated with susceptibility to SLE.
|
27726311 |
2016 |
|
rs77191406
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, two SLE patients carrying rs77191406 (heterozygous) had severe disease or developed bladder cancer 5 years after SLE diagnosis.
|
27435953 |
2016 |
|
rs5029941
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although A125V was associated with protection from SLE, surprisingly the same allele was associated with increased risk of inflammatory bowel disease.
|
20483768 |
2010 |