rs1917799
|
|
|
0.030 |
GeneticVariation |
BEFREE |
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026); and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012) and PGC rs9471643 polymorphism (P interaction = 0.039) were observed for the risk of atrophic gastritis.
|
24586594 |
2014 |
rs1917799
|
|
|
0.030 |
GeneticVariation |
BEFREE |
ERCC6 rs1917799 GG genotype might be associated with increased GC risk in Chinese, especially in males.
|
24289633 |
2013 |
rs1917799
|
|
|
0.030 |
GeneticVariation |
BEFREE |
ERCC6 rs1917799 also showed a significant interaction with ERCC8 rs158916 to reduce gastric cancer risk.
|
28562347 |
2017 |
rs12155758
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Although rs12155758 and rs9297976 were also found associated with GC, this association appeared to be due to linkage disequilibrium with rs2294008.
|
21681742 |
2012 |
rs12155758
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SNP rs12155758 was not associated with risk of gastric preneoplastic lesions, but we confirmed its association with higher GC risk (OR 1.95; 95% CI 1.29-2.97 for dominant model).
|
24023815 |
2013 |
rs36012910
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs36012910 allele G was associated with an increased risk of G</span>C compared to the rs36012910 allele A.
|
23053986 |
2012 |
rs36012910
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Lastly, a systematic review on 7 studies for 17 SNPs suggested that rs36012910, rs7560488 and rs6087990 might have a potential effect on GC initiation.
|
27789275 |
2016 |
rs4460629
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Two SNPs at 1q22, rs4072037 and rs4460629, were significantly associated with a reduced risk of GC, best fitting the dominant genetic model.
|
22938415 |
2012 |
rs4460629
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Recently, a genome-wide association study of gastric cancer (GC) reported the significant association of seven genetic variants (rs4072037 and rs4460629 on 1q22; rs753724, rs11187842, rs3765524, rs2274223, and rs3781264 on 10q23) with GC in a Chinese population.
|
22740136 |
2012 |
rs7560488
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest that the genetic variations in the DNMT3A1 promoter contribute to the susceptibility to GC and also provide an insight that tagSNP rs7560488 T>C may be a promising biomarker for predicting GC genetic susceptibility and a valuable information in GC pathogenesis.
|
24667323 |
2014 |
rs7560488
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Lastly, a systematic review on 7 studies for 17 SNPs suggested that rs36012910, rs7560488 and rs6087990 might have a potential effect on GC initiation.
|
27789275 |
2016 |
rs889312
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Cox regression analysis, log-rank test and Kaplan-Meier method were used to explore the link between MAP3K1 rs889312 variant and overall survival (OS) of GC.
|
31686841 |
2019 |
rs889312
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Considering steroid hormone-mediated signaling pathways have an important role in the progression of gastric cancer, we hypothesized that MAP3K1 rs889312 may be associated with survival outcomes in gastric cancer.
|
24759887 |
2014 |
rs10116253
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying CC genotype of rs10116253 and TT genotype of rs1927911 had a significantly decreased risk of GC (adjusted OR=0.33, 95% CI 0.18-0.60, P<0.001 and adjusted OR=0.37, 95% CI 0.21-0.67, P=0.001 respectively), compared with TT genotype of rs10116253 and CC genotype of rs1927911.
|
24365597 |
2014 |
rs10484761
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variation rs10484761 on 6p21.1 derived from a genome-wide association study is associated with gastric cancer survival in a Chinese population.
|
24325909 |
2014 |
rs10811474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ASSET analyses identified four SNPs significantly associated with multiple cancers: rs3731239 (CDKN2A intronic) with ESCC, GC and BC (P = 3.96 × 10(-) (4)); rs10811474 (3' of IFNW1) with RCC and BrC (P = 0.001); rs12683422 (LINGO2 intronic) with RCC and BC (P = 5.93 × 10(-) (4)) and rs10511729 (3' of ELAVL2) with LC and BrC (P = 8.63 × 10(-) (4)).
|
25239644 |
2014 |
rs10983755
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a case-control study, we analyzed the genotypic distribution of TLR4 rs10983755 (-2081G/A) and rs11536878 in a Chinese population and investigated the effect of their interactions with Helicobacter pylori infection on susceptibility to gastric cancer (GC) and atrophic gastritis (AG).
|
25084512 |
2014 |
rs11040869
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, minor allele homozygotes of rs3793964 and rs11040869 were significantly associated with a decreased risk of non-cardia gastric cancer when compared with their major allele homozygotes.
|
24935372 |
2014 |
rs11088680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
INSL3 rs10421916 and rs11088680 had both a 0.8-fold decreased OR for gastric cancer (95% CIs = 0.7-0.97; and 0.7-0.9, respectively).
|
23028900 |
2012 |
rs12083239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MFSD2A rs12083239 GC genotype and TRIT1 rs2172362 or rs230310 homozygous genotype were associated with Lauren's classification (GC versus GG, adjusted OR, 1.69; GC versus GG/CC, adjusted OR, 1.74) and tumor site (rs2172362: CC versus CT, adjusted OR, 1.71; CC/TT versus CT, adjusted OR, 1.62; rs230310: CC versus CT, adjusted OR, 1.75; CC/TT versus CT, adjusted OR, 1.67) of gastric cancer, respectively.
|
23349019 |
2013 |
rs12521436
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, we made a joint effect analysis of rs12521436, rs33388 and rs4912913 on risk of gastric cancer (<i>P<sub>Trend</sub></i> =2.83×10<sup>-5</sup>).
|
29285253 |
2017 |
rs12615966
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, genetic model analyses showed that rs2689154 was associated with a reduced risk of GC</span> under the recessive model (adjusted OR = 0.46, 95% CI: 0.22-0.98, P = 0.037), and rs12615966 in FOXF1 was associated with an increased risk of GC in both the dominant and log-additive models after adjusted for age and gender (adjusted OR = 1.36, 95% CI: 1.02-1.81, P = 0.033; adjusted OR = 1.36, 95% CI: 1.05-1.75, P = 0.018, respectively).
|
28404937 |
2017 |
rs12826786
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No statistically significant differences were found in the allele or genotype distributions of the HOTAIR rs12826786 C>T polymorphism among GC and healthy control subjects (P > 0.05).
|
28342055 |
2017 |
rs13361189
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, the rs13361189 IRGM polymorphism was not associated with susceptibility to gastric cancer.
|
22713085 |
2012 |
rs1887427
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The JAK2 gene rs2230724 and rs1887427 polymorphisms are associated with an increased risk of gastric cancer in a Chinese Han population.
|
23717640 |
2013 |