rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we did not find any association of polymorphism of XRCC1 Arg399Gln (OR = 1.56; 95% CI: 0.32-7.82) and XPD Lys751Gln (OR = 0.46; CI: 0.10-2.19) with GC risk in the study population.
|
30225185 |
2018 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, we suggest that the XRCC1 gene Arg194Trp polymorphism is associated with gastric cancer susceptibility in the Chinese population.
|
27706710 |
2016 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that XRCC1 gene rs25487 polymorphism might play a leading role in pronounced susceptibility to gastric cancer in Han Chinese.
|
26590607 |
2016 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We additionally found that the variant 399Gln allele in Arg399Gln SNP was associated with a greater risk of developing gastric cancer.
|
27221877 |
2016 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the XRCC1 Arg399Gln and Arg280His polymorphisms were shown to have no influence on the development of gastric cancer.
|
27706710 |
2016 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis aimed to summarize published data about the association between two SNPs of XRCC1 (Arg194Trp and Arg399Gln) and treatment outcomes of patients with advanced gastric cancer.
|
24465544 |
2014 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, significant associations between Arg194Trp polymorphism and gastric cancer were found in Asian.
|
25335737 |
2014 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis indicates that genetic polymorphism of the XRCC1 Arg399Gln and Arg280His do not have an association with gastric cancer risk.
|
25335737 |
2014 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis aimed to obtain a comprehensive and reliable assessment of the relationships between XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms and the clinical outcomes of gastric cancer (GC) patients treated with oxaliplatin-based chemotherapy.
|
24590266 |
2014 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis aimed to summarize published data about the association between two SNPs of XRCC1 (Arg194Trp and Arg399Gln) and treatment outcomes of patients with advanced gastric cancer.
|
24465544 |
2014 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The data suggest that the XRCC1 Arg399Gln polymorphism may be a prognostic biomarker of OS for platinum-based gastric cancer treatment.
|
24634242 |
2014 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that the genetic variant Arg280His in XRCC1 may contribute to cancer progression and that XRCC1 Arg194Trp variants may act as a favorable prognostic indicator of resected GC, particularly among the diffuse-type GC.
|
23425027 |
2013 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, XRCC1 Arg194Trp homozygous mutant genotype (Trp/Trp) was found to be associated with increased risk of GC.
|
21604176 |
2012 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In particular, individuals with the XRCC1 Arg194Trp variant genotype are at increased risk for GC below 60 years old.
|
23317230 |
2012 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China.
|
22901183 |
2012 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of the overall meta-analysis did not suggest any association between Arg280His/Arg399Gln polymorphisms and GC susceptibility for all genetic models.
|
21604176 |
2012 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found no evidence of a significant association between the XRCC1 Arg399Gln polymorphism and gastri</span>c cancer risk (in the additive inheritance model, OR = 0.986, 95%CI = 0.831-1.156, in the dominant inheritance model, OR = 1.044, 95%CI = 0.890-1.224 and in the recessive inheritance model, OR = 0.975, 95%CI = 0.894-1.063).
|
23212324 |
2012 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Arg399Gln SNP is not associated with the cardia type of gastric cancer.
|
21216841 |
2011 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphic variants of base excision repair (APE1-D148E, XRCC1-R194W, XRCC1-R399Q and OGG1-S326C), nucleotide excision repair (XPC-PAT, XPA-23G>A, ERCC1-19007T>C and XPD-L751Q), recombination (XRCC3-T241M) and alkylation damage reversal (MGMT-L84F) were tested for their potential role in the development of GC by using logistic regression models.
|
20817763 |
2010 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphic variants of base excision repair (APE1-D148E, XRCC1-R194W, XRCC1-R399Q and OGG1-S326C), nucleotide excision repair (XPC-PAT, XPA-23G>A, ERCC1-19007T>C and XPD-L751Q), recombination (XRCC3-T241M) and alkylation damage reversal (MGMT-L84F) were tested for their potential role in the development of GC by using logistic regression models.
|
20817763 |
2010 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase (ADPRT, Val762Ala), 8-oxoguanine DNA glycosylase (OGG1, Ser326Cys) and apurinic/apyrimidinic endonuclease 1 (APE1, Asp148Glu) and evolution of H.pylori-associated precancerous gastric lesions, a population-based cohort study was conducted in Linqu County, a high-risk area of gastric cancer in China.
|
19147860 |
2009 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase (ADPRT, Val762Ala), 8-oxoguanine DNA glycosylase (OGG1, Ser326Cys) and apurinic/apyrimidinic endonuclease 1 (APE1, Asp148Glu) and evolution of H.pylori-associated precancerous gastric lesions, a population-based cohort study was conducted in Linqu County, a high-risk area of gastric cancer in China.
|
19147860 |
2009 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association is found between the XRCC1 polymorphism Arg399Gln and gastric cancer risk.
|
19034980 |
2008 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population.
|
16425350 |
2005 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population.
|
16425350 |
2005 |