Gene: BRCA2 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs45580035
rs45580035
BRCA2
T 0.700 CausalMutation CLINVAR

dbSNP: rs80358683
rs80358683
BRCA2
T 0.700 CausalMutation CLINVAR

dbSNP: rs80359204
rs80359204
BRCA2
0.700 GeneticVariation UNIPROT

dbSNP: rs759851035
rs759851035
BRCA2
0.010 GeneticVariation BEFREE The c.9334G>A variant, classified as a rare variant of unknown significance, on current evidence may predisposes to cancers of the breast, prostate and melanoma. 30286154

2018
dbSNP: rs11571833
rs11571833
BRCA2
0.010 GeneticVariation BEFREE We also found a rare nonsense variant in the BRCA2 gene (rs11571833), previously associated with cancer susceptibility but not with melanoma, which showed weak association with melanoma susceptibility in the Swedish population. 27074266

2016
dbSNP: rs10492396
rs10492396
BRCA2
0.010 GeneticVariation BEFREE By performing false-positive report probability corrections and stepwise Cox proportional hazards regression analyses, we identified significant associations between CM OS and four putatively functional SNPs: BRCA2 rs10492396 (AG vs. GG: adjusted hazard ratio (adjHR)=1.85, 95% confidence interval (CI)=1.16-2.95, P=0.010), rs206118 (CC vs. TT+TC: adjHR=2.44, 95% CI=1.27-4.67, P=0.007), rs3752447 (CC vs. TT+TC: adjHR=2.10, 95% CI=1.38-3.18, P=0.0005), and FANCA rs62068372 (TT vs. CC+CT: adjHR=1.85, 95% CI=1.27-2.69, P=0.001). 25243787

2015
dbSNP: rs206118
rs206118
BRCA2
0.010 GeneticVariation BEFREE By performing false-positive report probability corrections and stepwise Cox proportional hazards regression analyses, we identified significant associations between CM OS and four putatively functional SNPs: BRCA2 rs10492396 (AG vs. GG: adjusted hazard ratio (adjHR)=1.85, 95% confidence interval (CI)=1.16-2.95, P=0.010), rs206118 (CC vs. TT+TC: adjHR=2.44, 95% CI=1.27-4.67, P=0.007), rs3752447 (CC vs. TT+TC: adjHR=2.10, 95% CI=1.38-3.18, P=0.0005), and FANCA rs62068372 (TT vs. CC+CT: adjHR=1.85, 95% CI=1.27-2.69, P=0.001). 25243787

2015
dbSNP: rs1799944
rs1799944
BRCA2
0.010 GeneticVariation BEFREE In conclusion, we report an increased melanoma risk among carriers of the N991D change of the BRCA2 and no association of the CHEK2 changes with malignant melanoma. 18024013

2008
dbSNP: rs886040456
rs886040456
BRCA2
0.010 GeneticVariation BEFREE In conclusion, we report an increased melanoma risk among carriers of the N991D change of the BRCA2 and no association of the CHEK2 changes with malignant melanoma. 18024013

2008