Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4938723
rs4938723
0.010 GeneticVariation BEFREE These findings indicate that rs4938723 in the promoter region of pri-miR-34b/c and the SNP in TP53 codon 72 were related to decreased risk of CRC in the population studied and those metabolic diseases and genetic variants influence each other with regard to CRC susceptibility. 24337371

2014

dbSNP: rs7076156
rs7076156
0.010 GeneticVariation BEFREE We evaluated the association of polymorphisms TaqI and FokI of VDR gene and Ala62Thr of ZNF365 gene with the metabolic disorders (MD) in children with urolithiasis (UL).We included 109 children with UL. 25060549

2014

dbSNP: rs738409
rs738409
0.040 GeneticVariation BEFREE I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease. 26148225

2015

dbSNP: rs2059806
rs2059806
0.020 GeneticVariation BEFREE The INSR rs2059806 SNP previously associated with adult vascular and metabolic diseases is also associated with SGA pregnancies. 26089371

2015

dbSNP: rs13702
rs13702
LPL
0.010 GeneticVariation BEFREE The LPL SNPs rs301 (T<C), rs328 (C<G) and rs13702 (T<C) have been associated with various metabolic disorders, but the association with CLL evolution is unknown. 25811490

2015

dbSNP: rs1800795
rs1800795
0.010 GeneticVariation BEFREE To date, several association studies examining rs1800795 allele frequency and disease risk have reported seemingly conflicting results ranging from no association to association with either the major or minor allele across a spectrum of conditions, including cancer and autoimmune, cardiovascular, infectious, and metabolic diseases. 26578807

2015

dbSNP: rs301
rs301
LPL
0.010 GeneticVariation BEFREE The LPL SNPs rs301 (T<C), rs328 (C<G) and rs13702 (T<C) have been associated with various metabolic disorders, but the association with CLL evolution is unknown. 25811490

2015

dbSNP: rs328
rs328
LPL
0.010 GeneticVariation BEFREE The LPL SNPs rs301 (T<C), rs328 (C<G) and rs13702 (T<C) have been associated with various metabolic disorders, but the association with CLL evolution is unknown. 25811490

2015

dbSNP: rs5767700
rs5767700
0.010 GeneticVariation BEFREE Eight single nucleotide polymorphisms in the PPARα gene were chosen from either the HapMap CHB database or previous reports.The distribution of metabolic disorders differed significantly between the wild-type and variant genotypes of both the rs5767743 and rs5767700 loci (P < 0.05 for all). 26334901

2015

dbSNP: rs5767743
rs5767743
0.010 GeneticVariation BEFREE Eight single nucleotide polymorphisms in the PPARα gene were chosen from either the HapMap CHB database or previous reports.The distribution of metabolic disorders differed significantly between the wild-type and variant genotypes of both the rs5767743 and rs5767700 loci (P < 0.05 for all). 26334901

2015

dbSNP: rs738409
rs738409
0.040 GeneticVariation BEFREE I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders. 26765961

2016

dbSNP: rs4994
rs4994
0.020 GeneticVariation BEFREE The aim of this study was to determine the relationship between PPAR gamma-2 (Pro12Ala, C1431T) and ADRB3 (Trp64Arg) polymorphisms and serum adipocytokines (adiponectin, visfatin, and resistin) and metabolic disorders in 176 postmenopausal women with increased body mass (BMI ≥ 25 kg m(-2)). 27246401

2016

dbSNP: rs1572982
rs1572982
HFE
0.010 GeneticVariation BEFREE Haplotype analysis for the rs1799945, rs1800730, rs1800562, rs2071303, rs1800708, and rs1572982 was performed on Russian patients with some metabolic disorders or stomach cancer and among long-lived people. 27317329

2016

dbSNP: rs1800544
rs1800544
0.010 GeneticVariation BEFREE Two Single Nucleotide Polymorphisms (SNPs) of the adrenergic receptor-2a gene (ADRA2A): rs1800544 and rs553668, have been associated to these metabolic disorders. 26563278

2016

dbSNP: rs553668
rs553668
0.010 GeneticVariation BEFREE Two Single Nucleotide Polymorphisms (SNPs) of the adrenergic receptor-2a gene (ADRA2A): rs1800544 and rs553668, have been associated to these metabolic disorders. 26563278

2016

dbSNP: rs2059806
rs2059806
0.020 GeneticVariation BEFREE Thus, it was found that the INSR rs2059806 SNP is also associated with pre-eclampsia phenotypes in two independent cohorts suggesting that genetic susceptibility may be implicated in the link between pre-eclampsia and subsequent vascular and metabolic diseases. 28117222

2017

dbSNP: rs1267969615
rs1267969615
ACE
0.010 GeneticVariation BEFREE The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acromegaly. 28712073

2017

dbSNP: rs150924946
rs150924946
0.010 GeneticVariation BEFREE Interestingly, this study also correlated novel variant p.K108E with psychiatric disease, identified known variant p.I299V as a potential risk factor for metabolic disease in Latinos, linked variant p.G602 with type 2 diabetes, and identified p.G602S as a predictor of diabetes risk in African Americans. 28663758

2017

dbSNP: rs16139
rs16139
0.010 GeneticVariation BEFREE A gain-of-function polymorphism in human neuropeptide Y (<i>NPY</i>) gene (rs16139) associates with metabolic disorders and earlier onset of type 2 diabetes (T2D). 28468933

2017

dbSNP: rs60662302
rs60662302
0.010 GeneticVariation BEFREE Interestingly, this study also correlated novel variant p.K108E with psychiatric disease, identified known variant p.I299V as a potential risk factor for metabolic disease in Latinos, linked variant p.G602 with type 2 diabetes, and identified p.G602S as a predictor of diabetes risk in African Americans. 28663758

2017

dbSNP: rs699
rs699
AGT
0.010 GeneticVariation BEFREE The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acromegaly. 28712073

2017

dbSNP: rs763751076
rs763751076
0.010 GeneticVariation BEFREE The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acromegaly. 28712073

2017

dbSNP: rs771065515
rs771065515
0.010 GeneticVariation BEFREE Interestingly, this study also correlated novel variant p.K108E with psychiatric disease, identified known variant p.I299V as a potential risk factor for metabolic disease in Latinos, linked variant p.G602 with type 2 diabetes, and identified p.G602S as a predictor of diabetes risk in African Americans. 28663758

2017

dbSNP: rs8192678
rs8192678
0.020 GeneticVariation BEFREE Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism. 29186342

2018

dbSNP: rs1799883
rs1799883
0.010 GeneticVariation BEFREE This study aimed to determine whether FABP2 (Ala54Thr) and MTTP (-493 G/T) genetic polymorphisms are associated with metabolic disorders in Mexican subjects. 29338565

2018