Moreover, we also found that there is a statistically significant association between rs3918242 polymorphism and myocardial infarction (MI) in Asians with allelic model (OR 1.66; 95% CI 1.29-2.14; <i>p</i> < 0.0001), recessive model (OR 2.29; 95% CI 1.44-3.63; <i>p</i> = 0.004), and dominant (OR 1.74; 95% CI 1.29-2.35; <i>p</i> = 0.0003) model.
Multiple logistic analysis was performed between MI patients and controls to estimate the risk, and after adjusting for identified risk factors, the CT + TT genotypes of MMP9 rs3918242 were found to be significantly associated with increased risk of developing MI than those with the CC genotype (OR = 2.88, P < 0.01).
The -1562C>T or R2</span>79Q polymorphism of MMP-9 gene and smoking have a synergistic effect and are significantly associated with the risk of MI in Chinese Uighur population, respectively.