|
rs524952
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Moreover, 15q14 variant rs524952 (p=0.015, OR=1.49) also showed mild association with myopia and high myopia.
|
31604699 |
2019 |
|
rs10034228
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The 4q25 variant rs10034228 (p=0.002, OR=0.56) and <i>MIPEP</i> variant rs9318086 (p=0.004, OR=1.62) were found to be significantly associated with myopia as well as different severity of myopia.
|
31604699 |
2019 |
|
rs9318086
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The 4q25 variant rs10034228 (p=0.002, OR=0.56) and <i>MIPEP</i> variant rs9318086 (p=0.004, OR=1.62) were found to be significantly associated with myopia as well as different severity of myopia.
|
31604699 |
2019 |
|
rs13382811
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The risk allele T of <i>ZC3H11B</i> SNP rs4373767 was significantly associated with high myopia (OR=1.39, p=0.007) and extreme myopia (OR=1.34, p=0.013) when compared with controls, whereas <i>ZFHX1B</i> rs13382811 (allele T, OR=1.33, p=0.018) and <i>SNTB1</i> rs7839488 (allele G, OR=1.71, p=8.44E-05) were significantly associated with extreme myopia only.
|
31300455 |
2019 |
|
rs9318086
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Based on previous myopia genome-wide association studies, five SNPs (<i>ZC3H11B</i> rs4373767, <i>ZFHX1B</i> rs13382811, <i>VIPR2</i> rs2730260, <i>SNTB1</i> rs7839488 and <i>MIPEP</i> rs9318086) were selected for genotyping in a Chinese cohort of 2079 subjects: 252 extreme myopia, 277 high myopia, 393 moderate myopia, 366 mild myopia and 791 non-myopic controls.
|
31300455 |
2019 |
|
rs4373767
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk allele T of <i>ZC3H11B</i> SNP rs4373767 was significantly associated with high myopia (OR=1.39, p=0.007) and extreme myopia (OR=1.34, p=0.013) when compared with controls, whereas <i>ZFHX1B</i> rs13382811 (allele T, OR=1.33, p=0.018) and <i>SNTB1</i> rs7839488 (allele G, OR=1.71, p=8.44E-05) were significantly associated with extreme myopia only.
|
31300455 |
2019 |
|
rs7839488
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk allele T of <i>ZC3H11B</i> SNP rs4373767 was significantly associated with high myopia (OR=1.39, p=0.007) and extreme myopia (OR=1.34, p=0.013) when compared with controls, whereas <i>ZFHX1B</i> rs13382811 (allele T, OR=1.33, p=0.018) and <i>SNTB1</i> rs7839488 (allele G, OR=1.71, p=8.44E-05) were significantly associated with extreme myopia only.
|
31300455 |
2019 |
|
rs339501
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found rs2973644 was significantly associated with increased risk of myopia (odds ratio [OR]: 1.26; 95% confidence intervals [CI]: 1.06-1.49; P = 0.009). furthermore, rs339501 (OR: 1.73; 95% CI: 1.18-2.53; P = 0.005), rs2973644 (OR: 1.57; 95% CI: 1.13-2.19; P = 0.007), and rs79002828 (OR: 1.83; 95% CI: 1.20-2.77; P = 0.005) were significantly associated with increased risk of high myopia in young children.
|
31021460 |
2019 |
|
rs2973644
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found rs2973644 was significantly associated with increased risk of myopia (odds ratio [OR]: 1.26; 95% confidence intervals [CI]: 1.06-1.49; P = 0.009). furthermore, rs339501 (OR: 1.73; 95% CI: 1.18-2.53; P = 0.005), rs2973644 (OR: 1.57; 95% CI: 1.13-2.19; P = 0.007), and rs79002828 (OR: 1.83; 95% CI: 1.20-2.77; P = 0.005) were significantly associated with increased risk of high myopia in young children.
|
31021460 |
2019 |
|
rs79002828
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found rs2973644 was significantly associated with increased risk of myopia (odds ratio [OR]: 1.26; 95% confidence intervals [CI]: 1.06-1.49; P = 0.009). furthermore, rs339501 (OR: 1.73; 95% CI: 1.18-2.53; P = 0.005), rs2973644 (OR: 1.57; 95% CI: 1.13-2.19; P = 0.007), and rs79002828 (OR: 1.83; 95% CI: 1.20-2.77; P = 0.005) were significantly associated with increased risk of high myopia in young children.
|
31021460 |
2019 |
|
rs747797174
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Myopia disease mouse models: a missense point mutation (S673G) and a protein-truncating mutation of the <i>Zfp644</i> mimic human disease phenotype.
|
30834109 |
2019 |
|
rs748448196
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Myopia disease mouse models: a missense point mutation (S673G) and a protein-truncating mutation of the <i>Zfp644</i> mimic human disease phenotype.
|
30834109 |
2019 |
|
rs662702
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Significant differences were detected between the PAX6 gene (rs662702) TT and CT genotypes in moderate and high degree myopia; the risk C allele increased the risk for myopia.
|
30453065 |
2019 |
|
rs10453441
|
|
|
0.020 |
GeneticVariation |
BEFREE |
WNT7B SNPs located in the same genomic region that includes rs9330813 have previously been associated with CCT in Latinos but with other ocular quantitative traits related to myopia (corneal curvature and axial length) in a Japanese population (rs10453441 and rs200329677).
|
29847655 |
2018 |
|
rs200329677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
WNT7B SNPs located in the same genomic region that includes rs9330813 have previously been associated with CCT in Latinos but with other ocular quantitative traits related to myopia (corneal curvature and axial length) in a Japanese population (rs10453441 and rs200329677).
|
29847655 |
2018 |
|
rs9330813
|
|
|
0.010 |
GeneticVariation |
BEFREE |
WNT7B SNPs located in the same genomic region that includes rs9330813 have previously been associated with CCT in Latinos but with other ocular quantitative traits related to myopia (corneal curvature and axial length) in a Japanese population (rs10453441 and rs200329677).
|
29847655 |
2018 |
|
rs634990
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Persons with combinations of genotypes rs634990 CC and rs8027411 GT have 2.7 times higher odds to have myopia.
|
29793445 |
2018 |
|
rs8027411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Persons with combinations of genotypes rs634990 CC and rs8027411 GT have 2.7 times higher odds to have myopia.
|
29793445 |
2018 |
|
rs11873439
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our two-stage genome-wide association study of myopic maculopathy identifies a susceptibility locus at rs11873439 in an intron of CCDC102B (P = 1.77 × 10<sup>-12</sup> and P<sub>corr</sub> = 1.61 × 10<sup>-10</sup>).
|
29725004 |
2018 |
|
rs644242
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study provides additional evidence suggesting that the <i>PAX6</i> SNP rs644242 is associated with extreme myopia but not lower grade myopia.
|
29436400 |
2018 |
|
rs662702
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A total of four haplotype-tagging single-nucleotide polymorphisms (SNPs; rs2071754, rs3026354, rs3026390 and rs628224) and two previously reported SNPs (rs644242 and rs662702) in the <i>PAX6</i> gene were analysed in a Hong Kong Chinese cohort of 1288 myopia subjects (including 252 extreme myopia, 277 high myopia, 393 moderate myopia and 366 mild myopia) and 791 no myopia controls.
|
29436400 |
2018 |
|
rs2071754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of tagging SNPs rs2071754 and rs644242 with extreme myopia could not withstand multiple correction (rs2071754: OR=1.25, P value=0.031; rs644242: OR=1.33, P value=0.032).
|
29436400 |
2018 |
|
rs1327062642
|
|
TG |
0.700 |
CausalMutation |
CLINVAR |
Antioxidant effect of aqueous extract of four plants with therapeutic potential on gynecological diseases; Semen persicae, Leonurus cardiaca, Hedyotis diffusa, and Curcuma zedoaria.
|
29178942 |
2017 |
|
rs1555639076
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features.
|
28942966 |
2017 |
|
rs7744813
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The SNP rs7744813, previously shown to be associated with refractive error and myopia in two GWAS, showed an odds ratio of 0.75 (95% CI 0.63-0.90; <i>P</i><sub>emp</sub> = 0.0058) for the minor allele.
|
28884119 |
2017 |