Gene: EGFR ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2227983
rs2227983
EGFR
0.020 GeneticVariation BEFREE A marked decrease on EGFR phosphorylation (P < 0.01) and c-Myc activation (P = 0.02) was observed in patients with R497K polymorphism, which is associated with decreased invasion (P = 0.01), lower nodal involvement (P = 0.02), reduced subsequent metastasis (P < 0.01), and longer disease-free (P < 0.01) as well as overall (P < 0.01) survival in stage II/III colorectal carcinoma patients who had received curative surgery. 17575224

2007
dbSNP: rs7795743
rs7795743
EGFR ; EGFR-AS1
0.010 GeneticVariation BEFREE The G allele in rs7795743 in EGFR had an OR for metastasis of 0.68 (p-value = 0.02) and hazard ratio (HR) for progression of 0.66 (p-value = 0.004). 30827726

2019
dbSNP: rs121913444
rs121913444
EGFR
0.010 GeneticVariation BEFREE Pyrosequencing of the primary pancreatic tumor antecedent to metastasis showed an uncommon EGFR mutation at L861Q in the kinase domain of exon 21. 29695402

2018
dbSNP: rs28929495
rs28929495
EGFR
0.010 GeneticVariation BEFREE We herein first report G719S mutation in lung adenocarcinoma with tonsillar metastasis. 29245278

2017
dbSNP: rs723526
rs723526
EGFR
0.010 GeneticVariation BEFREE Furthermore, in a meta-analysis, 3 additional SNPs were significantly associated with SLN metastasis (EGFR rs723526 and TLR3 rs3775292) and melanoma-specific death (TLR3 rs7668666). 23462921

2013