| Variant | Gene | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|
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0.040 | GeneticVariation | BEFREE | The T790M resistance mutation was detected in metastases in 3 patients with acquired resistance to EGFR tyrosine kinase inhibitors. | 26968843 | 2016 |
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0.040 | GeneticVariation | BEFREE | A concomitant squamous histology transformation in a lung non-T790M-resistant metastasis is also described. | 24029120 | 2014 |
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0.040 | GeneticVariation | BEFREE | : Our results imply that blockade of the TGF-β signaling pathway combined with continuous EGFR TKI treatment will be beneficial in preventing metastasis in patients with EGFR TKI-resistant NSCLC without the EGFR T790M resistance mutation. | 23334091 | 2013 |
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0.040 | GeneticVariation | BEFREE | In an autopsy case, the T790M mutation was found in multiple visceral metastases but not in a brain lesion. | 17085664 | 2007 |
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0.010 | GeneticVariation | BEFREE | Furthermore, in a meta-analysis, 3 additional SNPs were significantly associated with SLN metastasis (EGFR rs723526 and TLR3 rs3775292) and melanoma-specific death (TLR3 rs7668666). | 23462921 | 2013 |
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0.010 | GeneticVariation | BEFREE | Eligible participants were adults (> 18 years) with NSCLC and EGFR mutations (exon 19 deletion or L858R mutation in exon 21) with no history of chemotherapy for metastatic disease (neoadjuvant or adjuvant chemotherapy ending ≥ 6 months before study entry was allowed). | 22285168 | 2012 |