Additionally, a significant association with tumor grade was also observed for the rs603965 polymorphism in G versus A (allele comparison, p = 0.02, OR = 0.74, 95% CI 0.59-0.95, I<sup>2</sup> = 26%).
The C allele of <i>BRCA2</i>:rs15869 (OR, 1.600; <i>p</i>=0.041) and the C allele of <i>CCND1</i>:rs7177 (OR, 1.555; <i>p</i>=0.041) were associated with high tumor histologic grade.
The most significant association of CCND1 SNP rs3212879 with estrogen receptor-negative tumor types (P = 0.001) did not reach genome-wide significance levels.