|
rs1799782
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, subgroup analysis by ethnicities demonstrated that Gln/Arg genotype of Arg399Gln polymorphism was associated with increased risk of NMSC under the heterogeneous model in Asian populations (Gln/Arg vs Arg/Arg: OR =1.39, 95% CI =1.04-1.87, <i>P</i>=0.03); subgroup analysis by tumor types showed that Trp/Trp genotype of Arg194Trp was positively associated with decreased cancer risk in squamous-cell skin cancer (SCC) type under the homogeneous model (Trp/Trp vs Arg/Arg: OR =0.38, 95% CI =0.16-0.92, <i>P</i>=0.03).
|
28761356 |
2017 |
|
rs25487
|
|
|
0.050 |
GeneticVariation |
BEFREE |
ERCC1 Lys259Thr (rs735482), ERCC2 Lys751Gln (rs13181), ERCC5 His46His C>T (rs1047768), XRCC1 Arg399Gln (rs25487), TP53 Arg72Pro (rs1042522) and MDM2 309T>G (rs2279744) were analyzed on tumor DNA.
|
28351583 |
2017 |
|
rs25487
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, subgroup analysis by ethnicities demonstrated that Gln/Arg genotype of Arg399Gln polymorphism was associated with increased risk of NMSC under the heterogeneous model in Asian populations (Gln/Arg vs Arg/Arg: OR =1.39, 95% CI =1.04-1.87, <i>P</i>=0.03); subgroup analysis by tumor types showed that Trp/Trp genotype of Arg194Trp was positively associated with decreased cancer risk in squamous-cell skin cancer (SCC) type under the homogeneous model (Trp/Trp vs Arg/Arg: OR =0.38, 95% CI =0.16-0.92, <i>P</i>=0.03).
|
28761356 |
2017 |
|
rs25487
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Stratified analyses revealed that A/A + G/A genotypes of XRCC1 rs25487 are associated with significantly reduced risk of death compared with the G/G genotype in patients grouped by tumor size, portal vein tumor thrombus (PVTT), alpha-fetoprotein (AFP) and TNM stage (all p < 0.05).
|
26918371 |
2016 |
|
rs1799782
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Subgroup analyses according to ethnicity, tumor site, publication year, genotyping method also detected no significant association in any subgroup, except that oral cancer was associated with Arg194Trp variant in recessive model.
|
24086310 |
2013 |
|
rs25487
|
|
|
0.050 |
GeneticVariation |
BEFREE |
ERCC1 (C8092A, C118T), XPD (Lys751Gln), XRCC1 (Arg399Gln) and XRCC3 (Thr241Met) gene polymorphisms were evaluated on tumour DNA by TaqMan allelic discrimination assay.
|
23549037 |
2013 |
|
rs25487
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The results show strong evidence that the variant (C) allele confers significant increased risk in the Chinese (OR 1.20-1.44, P < 0.0001-0.002), exacerbated by smoking (OR 1.66-2.53, P < 0.0001) and joint interaction with XRCC1 Arg399Gln (OR 1.39, P < 0.0001) as well as adjustment for tumor type (gastric carcinoma ORs 1.39-2.01, P < 0.0001).
|
23073772 |
2012 |
|
rs1799782
|
|
|
0.050 |
GeneticVariation |
BEFREE |
No significant association was observed in stratified analyses of Arg399Gln and Arg194Trp polymorphisms by tumor type, race, or control source.
|
22110224 |
2011 |
|
rs1799782
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The XRCC1 R194W polymorphism was associated with a modest increased risk of TP53 tumor mutations in those who regularly smoked cigarettes (odds ratio, 1.4; 95% confidence interval, 1.02-1.9).
|
19959686 |
2009 |
|
rs1799782
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our meta-analysis on total of 11,957 cancer cases and 14,174 control subjects from 38 published case-control studies showed that the odds ratio (OR) for the variant genotypes (Trp/Trp + Arg/Trp) of the Arg194Trp polymorphism, compared with the wild-type homozygote (Arg/Arg), was 0.89 [95% confidence interval (95% CI), 0.81-0.98] for all tumor types without between-study heterogeneity.
|
16030121 |
2005 |
|
rs3213245
|
|
|
0.010 |
GeneticVariation |
BEFREE |
OS patients carrying TC genotype and C allele at rs3213245 were more likely to be with larger tumor size and metastasis.
|
30464596 |
2018 |
|
rs25489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the wide genotype GG of X-ray repair cross-complementing 1 (<i>XRCC1</i>) rs25489 (GG vs GA: OR=3.833, 95%CI=1.512-9.714, <i>P</i>=0.005; GG vs GA+AA: OR=3.610, 95%CI=1.496-8.713, <i>P</i>=0.004) and the wide genotype CC of 8-oxoguanine DNA glycosylase (<i>OGG1</i>) rs1052133 (CC vs GG: OR=0.263, 95%CI=0.073-0.951, <i>P</i>=0.042; CC vs CG+GG: OR=0.454, 95%CI=0.195-1.053, <i>P</i>=0.066) were positively and negatively associated with primary tumor efficacy at the end of radiotherapy, respectively.
|
29108254 |
2017 |
|
rs377566281
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition to tumour stage, which is an important prognostic factor affecting to the survival of stomach cancer patients, the genetic variant Gln339Arg in XRCC1 may non-significantly contribute to risk of stomach cancer death among Thai people.
|
26320504 |
2015 |