Gene: RET ×
Source: CLINVAR ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs143795581
rs143795581
RET
G 0.700 CausalMutation CLINVAR Nine novel germline gene variants in the RET proto-oncogene identified in twelve unrelated cases. 15858153

2005
dbSNP: rs143795581
rs143795581
RET
G 0.700 CausalMutation CLINVAR Functional characterization of the MTC-associated germline RET-K666E mutation: evidence of oncogenic potential enhanced by the G691S polymorphism. 21690267

2011
dbSNP: rs143795581
rs143795581
RET
G 0.700 CausalMutation CLINVAR Actionable exomic incidental findings in 6503 participants: challenges of variant classification. 25637381

2015
dbSNP: rs146646971
rs146646971
RET
C 0.700 CausalMutation CLINVAR Four novel RET germline variants in exons 8 and 11 display an oncogenic potential in vitro. 20103606

2010
dbSNP: rs146646971
rs146646971
RET
T 0.700 CausalMutation CLINVAR Recommendations for somatic and germline genetic testing of single pheochromocytoma and paraganglioma based on findings from a series of 329 patients. 26269449

2015
dbSNP: rs146646971
rs146646971
RET
T 0.700 CausalMutation CLINVAR Actionable exomic incidental findings in 6503 participants: challenges of variant classification. 25637381

2015
dbSNP: rs146646971
rs146646971
RET
C 0.700 CausalMutation CLINVAR Recommendations for somatic and germline genetic testing of single pheochromocytoma and paraganglioma based on findings from a series of 329 patients. 26269449

2015
dbSNP: rs146646971
rs146646971
RET
C 0.700 CausalMutation CLINVAR Nine novel germline gene variants in the RET proto-oncogene identified in twelve unrelated cases. 15858153

2005
dbSNP: rs146646971
rs146646971
RET
C 0.700 CausalMutation CLINVAR A newly identified missense mutation in RET codon 666 is associated with the development of medullary thyroid carcinoma. 25319874

2014
dbSNP: rs146646971
rs146646971
RET
C 0.700 CausalMutation CLINVAR Screening for germline mutations in breast/ovarian cancer susceptibility genes in high-risk families in Israel. 26687385

2016
dbSNP: rs146646971
rs146646971
RET
T 0.700 CausalMutation CLINVAR Medullary Thyroid Carcinoma Associated with Germline RETK666N Mutation. 27673361

2016
dbSNP: rs146646971
rs146646971
RET
C 0.700 CausalMutation CLINVAR Functional characterization of the MTC-associated germline RET-K666E mutation: evidence of oncogenic potential enhanced by the G691S polymorphism. 21690267

2011
dbSNP: rs146646971
rs146646971
RET
C 0.700 CausalMutation CLINVAR Predicting phenotypic severity of uncertain gene variants in the RET proto-oncogene. 21479187

2011
dbSNP: rs146646971
rs146646971
RET
T 0.700 CausalMutation CLINVAR Nine novel germline gene variants in the RET proto-oncogene identified in twelve unrelated cases. 15858153

2005
dbSNP: rs146646971
rs146646971
RET
C 0.700 CausalMutation CLINVAR Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. 25810047

2015
dbSNP: rs146646971
rs146646971
RET
C 0.700 CausalMutation CLINVAR Coexistence of multiple endocrine neoplasia type 1 and type 2 in a large Italian family. 21678021

2011
dbSNP: rs146646971
rs146646971
RET
C 0.700 CausalMutation CLINVAR Medullary Thyroid Carcinoma Associated with Germline RETK666N Mutation. 27673361

2016
dbSNP: rs146646971
rs146646971
RET
T 0.700 CausalMutation CLINVAR Four novel RET germline variants in exons 8 and 11 display an oncogenic potential in vitro. 20103606

2010
dbSNP: rs377767397
rs377767397
RET
A 0.700 CausalMutation CLINVAR Mutation analysis of the RET proto-oncogene in Dutch families with MEN 2A, MEN 2B and FMTC: two novel mutations and one de novo mutation for MEN 2A. 8557249

1996
dbSNP: rs377767397
rs377767397
RET
A 0.700 CausalMutation CLINVAR Different RET gene mutation-induced multiple endocrine neoplasia type 2A in 3 Chinese families. 28099363

2017
dbSNP: rs377767397
rs377767397
RET
A 0.700 CausalMutation CLINVAR Distribution of RET Mutations in Multiple Endocrine Neoplasia 2 in Denmark 1994-2014: A Nationwide Study. 27809725

2017
dbSNP: rs377767397
rs377767397
RET
A 0.700 CausalMutation CLINVAR Unusual clinical presentation of a patient with multiple endocrine neoplasia type 2A. 11395220

2001
dbSNP: rs377767397
rs377767397
RET
A 0.700 CausalMutation CLINVAR Mutation screening in a Norwegian cohort with pheochromocytoma. 23407919

2013
dbSNP: rs377767397
rs377767397
RET
A 0.700 CausalMutation CLINVAR Sporadic versus familial medullary thyroid microcarcinoma: a histopathologic study of 50 consecutive patients. 11688458

2001
dbSNP: rs377767406
rs377767406
RET
T 0.700 CausalMutation CLINVAR A patient with MEN 2 and multiple mutations of RET in the germline. 11149622

2000