Gene: TH2LCRR ×
Source: CLINVAR ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs778555849
rs778555849
RAD50 ; TH2LCRR
T 0.700 CausalMutation CLINVAR The frequency of cancer predisposition gene mutations in hereditary breast and ovarian cancer patients in Taiwan: From BRCA1/2 to multi-gene panels. 28961279

2017
dbSNP: rs1060501933
rs1060501933
RAD50 ; TH2LCRR
A 0.700 GeneticVariation CLINVAR Human RAD50 makes a functional DNA-binding complex. 25828805

2015
dbSNP: rs876658770
rs876658770
RAD50 ; TH2LCRR
T 0.700 GeneticVariation CLINVAR Human RAD50 makes a functional DNA-binding complex. 25828805

2015
dbSNP: rs1060501933
rs1060501933
RAD50 ; TH2LCRR
A 0.700 GeneticVariation CLINVAR Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study. 24894818

2014
dbSNP: rs786202259
rs786202259
RAD50 ; TH2LCRR
C 0.700 CausalMutation CLINVAR Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study. 24894818

2014
dbSNP: rs876658770
rs876658770
RAD50 ; TH2LCRR
T 0.700 GeneticVariation CLINVAR Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes. 24549055

2014
dbSNP: rs876658770
rs876658770
RAD50 ; TH2LCRR
T 0.700 CausalMutation CLINVAR Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes. 24549055

2014
dbSNP: rs876658770
rs876658770
RAD50 ; TH2LCRR
T 0.700 GeneticVariation CLINVAR Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study. 24894818

2014
dbSNP: rs876659654
rs876659654
RAD50 ; TH2LCRR
T 0.700 CausalMutation CLINVAR Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study. 24894818

2014
dbSNP: rs876659654
rs876659654
RAD50 ; TH2LCRR
T 0.700 CausalMutation CLINVAR ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair. 21441914

2011
dbSNP: rs786202259
rs786202259
RAD50 ; TH2LCRR
C 0.700 CausalMutation CLINVAR Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. 21035407

2010
dbSNP: rs876659654
rs876659654
RAD50 ; TH2LCRR
T 0.700 CausalMutation CLINVAR Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. 21035407

2010
dbSNP: rs151131414
rs151131414
RAD50 ; TH2LCRR
C 0.700 GeneticVariation CLINVAR Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder. 19409520

2009
dbSNP: rs761168506
rs761168506
RAD50 ; TH2LCRR
C 0.700 GeneticVariation CLINVAR Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder. 19409520

2009
dbSNP: rs995265408
rs995265408
RAD50 ; TH2LCRR
T 0.700 GeneticVariation CLINVAR Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder. 19409520

2009
dbSNP: rs876659654
rs876659654
RAD50 ; TH2LCRR
T 0.700 CausalMutation CLINVAR Learning our ABCs: Rad50 directs MRN repair functions via adenylate kinase activity from the conserved ATP binding cassette. 17386254

2007
dbSNP: rs151131414
rs151131414
RAD50 ; TH2LCRR
C 0.700 GeneticVariation CLINVAR Evaluation of RAD50 in familial breast cancer predisposition. 16385572

2006
dbSNP: rs761168506
rs761168506
RAD50 ; TH2LCRR
C 0.700 GeneticVariation CLINVAR Evaluation of RAD50 in familial breast cancer predisposition. 16385572

2006
dbSNP: rs995265408
rs995265408
RAD50 ; TH2LCRR
T 0.700 GeneticVariation CLINVAR Evaluation of RAD50 in familial breast cancer predisposition. 16385572

2006
dbSNP: rs1060501933
rs1060501933
RAD50 ; TH2LCRR
A 0.700 GeneticVariation CLINVAR Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. 10892749

2000
dbSNP: rs876658770
rs876658770
RAD50 ; TH2LCRR
T 0.700 GeneticVariation CLINVAR Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. 10892749

2000
dbSNP: rs1423570602
rs1423570602
RAD50 ; TH2LCRR
A 0.700 CausalMutation CLINVAR

dbSNP: rs1554100863
rs1554100863
RAD50 ; TH2LCRR
TTA 0.700 CausalMutation CLINVAR

dbSNP: rs1554100940
rs1554100940
RAD50 ; TH2LCRR
G 0.700 CausalMutation CLINVAR

dbSNP: rs1554100942
rs1554100942
RAD50 ; TH2LCRR
G 0.700 CausalMutation CLINVAR