|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For MTHFD1 rs2236225 polymorphism, mothers having GA genotype and A allele exhibited an increased risk of NTDs in the offspring (OR = 2.600, 95%CI: 1.227-5.529; OR = 1.847, 95%CI: 1.047-3.259).
|
30867013 |
2019 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For rs2236225 within MTHFD1, children with allele A or genotype AA had a high NTDs risk (OR=1.500, 95%CI=1.061~2.120; OR=2.862, 95%CI=1.022~8.015, respectively).
|
29392422 |
2018 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our research provides the first evidence supporting a paternal, rather than a maternal, transmission bias of MTHFD1 G1958A variant for NTD susceptibility in the offspring.
|
26394717 |
2016 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The haplotype GGGG, which consists of 4 SNPs (rs2236225, rs2236224, rs1256146, and rs6573559), is also associated with risk of NTDs (P value=0.0438, OR=0.7180, 95% CI=0.5214-0.9888).
|
26343515 |
2015 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, there was no significant association between the MTHFD1 G1958A polymorphism in NTD patients and the risk of NTD.
|
25502174 |
2015 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our analysis implicated that MTHFD1 1958G>A was significantly associated with the susceptibility of NTD in a Chinese population.
|
25524527 |
2015 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, our meta-analysis strongly suggests that the MTHFD1 G1958A polymorphism might be associated with maternal risk for NTDs in Caucasian populations.
|
24977710 |
2014 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFD1 p.R653Q has been proposed as a risk factor for neural tube defects (NTDs), congenital heart defects (CHDs) and pregnancy losses.
|
23704330 |
2013 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ten strongest association signals (p-value range: 0.0003-0.0023) were found in nine genes (MFTC, CDKN2A, ADA, PEMT, CUBN, GART, DNMT3A, MTHFD1 and T (Brachyury)) and included the known NTD risk factor MTHFD1 R653Q (rs2236225).
|
22856873 |
2012 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ten strongest association signals (p-value range: 0.0003-0.0023) were found in nine genes (MFTC, CDKN2A, ADA, PEMT, CUBN, GART, DNMT3A, MTHFD1 and T (Brachyury)) and included the known NTD risk factor MTHFD1 R653Q (rs2236225).
|
22856873 |
2012 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated this SNP as a potential risk factor for NTDs in a large homogenous Irish population and determined that it is not an independent risk factor, but, it does increase both case (chi (2) = 11.06, P = 0.001) and maternal (chi (2) = 6.68, P = 0.01) risk when allele frequencies were analysed in combination with the previously identified disease-associated p.R653Q (c.1958 G > A; dbSNP rs2236225) polymorphism.
|
19130090 |
2009 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common variant in MTHFD1, p.Arg653Gln (c.1958G>A), may increase the risk for neural tube defects (NTD).
|
18767138 |
2009 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common variant in MTHFD1, p.Arg653Gln (c.1958G>A), may increase the risk for neural tube defects (NTD).
|
18767138 |
2009 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, our results indicate that heterozygosity and homozygosity for the MTHFD1 1958G > A polymorphism are genetic determinants of NTD risk in the cases examined.
|
16315005 |
2006 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have established that the MTHFD1 1958G>A polymorphism has a significant role in influencing a mother's risk of having an NTD-affected pregnancy in the Irish population.
|
16552426 |
2006 |
|
rs2236225
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One SNP, R653Q, in this gene appears to be associated with NTD risk.
|
12384833 |
2002 |
|
rs1256146
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype GGGG, which consists of 4 SNPs (rs2236225, rs2236224, rs1256146, and rs6573559), is also associated with risk of NTDs (P value=0.0438, OR=0.7180, 95% CI=0.5214-0.9888).
|
26343515 |
2015 |
|
rs17857382
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the other two SNPs (401A>G and 2305C>T) displayed no statistically significant association with NTD risk.
|
25524527 |
2015 |
|
rs1950902
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the other two SNPs (401A>G and 2305C>T) displayed no statistically significant association with NTD risk.
|
25524527 |
2015 |
|
rs56811449
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphism of SNP loci rs1956545 and rs56811449 as well as a haplotype in MTHFD1 gene could serve as an indicator for the occurrence of NTDs in Chinese population and some specific genotypes of the loci may have lower risk of developing NTDs.
|
26343515 |
2015 |
|
rs6573559
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype GGGG, which consists of 4 SNPs (rs2236225, rs2236224, rs1256146, and rs6573559), is also associated with risk of NTDs (P value=0.0438, OR=0.7180, 95% CI=0.5214-0.9888).
|
26343515 |
2015 |