|
rs1150757
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica.
|
29769526 |
2018 |
|
rs28383224
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica.
|
29769526 |
2018 |
|
rs117026326
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the T allele of rs117026326 was associated with susceptibility to neuromyelitis optica spectrum disorders, and the CC genotype of rs73366469 conferred susceptibility to AQP4-IgG-seropositivity in Han Chinese patients.
|
30531019 |
2019 |
|
rs117026326
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We observed a significant genetic association between the variant rs117026326</span> and NMOSD (P = 1.09 × 10<sup>-11</sup>, OR = 2.535), however, the association with MS was not significant (P = .4289, OR = 1.129).
|
31520790 |
2019 |
|
rs1800693
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among the 35 SNPs, only one, rs1800693 in the TNFRSF1A locus, was nominally associated with NMO (P = 0.045, OR = 1.550, 95% CI = 1.007-2.384).
|
24927785 |
2014 |
|
rs1800693
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Logistic analyses revealed that one SNP in CD6 (rs12288280, P = 0.04) and three SNPs in TNFRSF1A (rs767455, rs4149577 and rs1800693, P = 0.01-0.03) were associated with NMO.
|
22994200 |
2013 |
|
rs2300747
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Based on previous studies, we suspect that the A allele of rs2300747 may decrease CD58 RNA expression, thus increasing NMO risk.
|
24655566 |
2014 |
|
rs2300747
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Five SNPs were significantly associated with an increased risk of NMOSD (rs2300747, rs1335532, rs56302466, rs1016140, and rs12044852).
|
28601281 |
2017 |
|
rs1016140
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, we deduced that the G allele of rs1016140 caused an increase of T cell activity, which in turn eased the access of AQP4 antibody into central nervous system (CNS) and ultimately leading to NMO development.
|
24655566 |
2014 |
|
rs10168266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004).
|
28852993 |
2017 |
|
rs10181656
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004).
|
28852993 |
2017 |
|
rs10876994
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the frequencies of the A allele of rs703842 were higher in MS patients than controls (p=0.032), and statistical differences were observed in the genotypes of both rs703842 (p=0.013) and rs10876994 (p=0.001) between NMO patients and controls.
|
25542806 |
2015 |
|
rs12044852
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five SNPs were significantly associated with an increased risk of NMOSD (rs2300747, rs1335532, rs56302466, rs1016140, and rs12044852).
|
28601281 |
2017 |
|
rs12288280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic analyses revealed that one SNP in CD6 (rs12288280, P = 0.04) and three SNPs in TNFRSF1A (rs767455, rs4149577 and rs1800693, P = 0.01-0.03) were associated with NMO.
|
22994200 |
2013 |
|
rs1234315
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To evaluate whether TNFSF4 polymorphisms contribute to risk of NMOSD, four single-nucleotide polymorphisms (SNPs) (rs1234315, rs2205960, rs704840, and rs844648) were selected and genotyped in a cohort of 312 patients with NMOSD and 487 healthy controls.
|
29032462 |
2017 |
|
rs13426947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004).
|
28852993 |
2017 |
|
rs1411751
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a subgroup analysis, rs1411751 was found to be associated with NMO (OR=0.36, P(corr)=0.03), and rs9523762 was marginally associated with both NMO and MS.
|
24135429 |
2013 |
|
rs150587304
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In 3 patients with NMO (2 related), we detected 2 different missense allelic mutations at Arg19 (R19I and R19T).
|
21900637 |
2011 |
|
rs1520333
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study suggested that among Chinese Han population in southeastern China, the variant of IL-7RA (rs6897932) was associated with NMO especially NMO-IgG positive patients while the variant of IL-7 (rs1520333) with MS patients.
|
26608987 |
2015 |
|
rs1883832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other three SNPs showed protections on NMOSD in dominant models (rs6074022, OR = 0.64, 95 % CI 0.42-0.95, P = 0.031; rs1883832, OR = 0.65, 95 % CI 0.43-0.97, P = 0.036; and rs4810485, OR = 0.63, 95 % CI 0.42-0.95, P = 0.029, respectively), but not significantly after Bonferroni corrections for multiple tests.
|
27578014 |
2017 |
|
rs2075575
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that the T allele of rs2075575 is a risk for AQP4-Ab-positive NMO.
|
27012886 |
2016 |
|
rs2282284
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Fc Receptor-Like 3 Polymorphisms (rs7528684, rs945635, rs3761959 and rs2282284) and The Risk of Neuromyelitis Optica in A Chinese Population.
|
26402798 |
2015 |
|
rs2887502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
And the genotypic differences of IL-7 rs2887502 between MS and NMO indicated the different genetic backgrounds of these two diseases.
|
26608987 |
2015 |
|
rs3135388
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HLA-DRB1*1501 tagging rs3135388 polymorphism is not associated with neuromyelitis optica.
|
20591987 |
2010 |
|
rs3761959
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Fc Receptor-Like 3 Polymorphisms (rs7528684, rs945635, rs3761959 and rs2282284) and The Risk of Neuromyelitis Optica in A Chinese Population.
|
26402798 |
2015 |