|
rs3808607
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stronger association between the variables and subsequently, a higher protective effect (lower OR) on the risk of NMO were observed among patients carrying the "G/G" genotype of rs3808607 than those with the "T/G" genotype (OR=0.38/P=0.01 vs. OR=0.12/P=0.0004, respectively).
|
19850125 |
2010 |
|
rs3135388
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HLA-DRB1*1501 tagging rs3135388 polymorphism is not associated with neuromyelitis optica.
|
20591987 |
2010 |
|
rs150587304
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In 3 patients with NMO (2 related), we detected 2 different missense allelic mutations at Arg19 (R19I and R19T).
|
21900637 |
2011 |
|
rs763780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs763780 T allele and TT genotype may increase susceptibility to NMO in the Southern Han Chinese.
|
22118860 |
2012 |
|
rs1800693
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Logistic analyses revealed that one SNP in CD6 (rs12288280, P = 0.04) and three SNPs in TNFRSF1A (rs767455, rs4149577 and rs1800693, P = 0.01-0.03) were associated with NMO.
|
22994200 |
2013 |
|
rs12288280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic analyses revealed that one SNP in CD6 (rs12288280, P = 0.04) and three SNPs in TNFRSF1A (rs767455, rs4149577 and rs1800693, P = 0.01-0.03) were associated with NMO.
|
22994200 |
2013 |
|
rs4149577
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic analyses revealed that one SNP in CD6 (rs12288280, P = 0.04) and three SNPs in TNFRSF1A (rs767455, rs4149577 and rs1800693, P = 0.01-0.03) were associated with NMO.
|
22994200 |
2013 |
|
rs767455
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic analyses revealed that one SNP in CD6 (rs12288280, P = 0.04) and three SNPs in TNFRSF1A (rs767455, rs4149577 and rs1800693, P = 0.01-0.03) were associated with NMO.
|
22994200 |
2013 |
|
rs422951
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DNA sequencing was used to genotype 106 NMO/NMOSD patients, 118 MS patients and 152 healthy controls (HCs) for rs422951.
|
23549433 |
2013 |
|
rs1411751
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a subgroup analysis, rs1411751 was found to be associated with NMO (OR=0.36, P(corr)=0.03), and rs9523762 was marginally associated with both NMO and MS.
|
24135429 |
2013 |
|
rs9523762
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a subgroup analysis, rs1411751 was found to be associated with NMO (OR=0.36, P(corr)=0.03), and rs9523762 was marginally associated with both NMO and MS.
|
24135429 |
2013 |
|
rs2300747
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Based on previous studies, we suspect that the A allele of rs2300747 may decrease CD58 RNA expression, thus increasing NMO risk.
|
24655566 |
2014 |
|
rs1016140
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, we deduced that the G allele of rs1016140 caused an increase of T cell activity, which in turn eased the access of AQP4 antibody into central nervous system (CNS) and ultimately leading to NMO development.
|
24655566 |
2014 |
|
rs1800693
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among the 35 SNPs, only one, rs1800693 in the TNFRSF1A locus, was nominally associated with NMO (P = 0.045, OR = 1.550, 95% CI = 1.007-2.384).
|
24927785 |
2014 |
|
rs548234
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the cohort of NMO patients, we observed that the CC genotype of rs548234 increased susceptibility to NMO (p = 0.016), while the allele T of rs548234 (p = 0.003) and the allele A of rs6937876 (p = 0.009) acted as protective factors for NMO-IgG positive NMO patients.
|
24953774 |
2014 |
|
rs6937876
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the cohort of NMO patients, we observed that the CC genotype of rs548234 increased susceptibility to NMO (p = 0.016), while the allele T of rs548234 (p = 0.003) and the allele A of rs6937876 (p = 0.009) acted as protective factors for NMO-IgG positive NMO patients.
|
24953774 |
2014 |
|
rs10876994
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the frequencies of the A allele of rs703842 were higher in MS patients than controls (p=0.032), and statistical differences were observed in the genotypes of both rs703842 (p=0.013) and rs10876994 (p=0.001) between NMO patients and controls.
|
25542806 |
2015 |
|
rs703842
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the frequencies of the A allele of rs703842 were higher in MS patients than controls (p=0.032), and statistical differences were observed in the genotypes of both rs703842 (p=0.013) and rs10876994 (p=0.001) between NMO patients and controls.
|
25542806 |
2015 |
|
rs2282284
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Fc Receptor-Like 3 Polymorphisms (rs7528684, rs945635, rs3761959 and rs2282284) and The Risk of Neuromyelitis Optica in A Chinese Population.
|
26402798 |
2015 |
|
rs3761959
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Fc Receptor-Like 3 Polymorphisms (rs7528684, rs945635, rs3761959 and rs2282284) and The Risk of Neuromyelitis Optica in A Chinese Population.
|
26402798 |
2015 |
|
rs945635
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Fc Receptor-Like 3 Polymorphisms (rs7528684, rs945635, rs3761959 and rs2282284) and The Risk of Neuromyelitis Optica in A Chinese Population.
|
26402798 |
2015 |
|
rs1520333
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study suggested that among Chinese Han population in southeastern China, the variant of IL-7RA (rs6897932) was associated with NMO especially NMO-IgG positive patients while the variant of IL-7 (rs1520333) with MS patients.
|
26608987 |
2015 |
|
rs2887502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
And the genotypic differences of IL-7 rs2887502 between MS and NMO indicated the different genetic backgrounds of these two diseases.
|
26608987 |
2015 |
|
rs6897932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study suggested that among Chinese Han population in southeastern China, the variant of IL-7RA (rs6897932) was associated with NMO especially NMO-IgG positive patients while the variant of IL-7 (rs1520333) with MS patients.
|
26608987 |
2015 |
|
rs773144793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Exome analysis in 212 MS and 14 NMO patients identified a rare CH25H p.Q17H mutation in two NMO patients of Asian ancestry.
|
26857497 |
2016 |