|
rs1044396
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Against this background, we investigated the association between harm avoidance and the rs1044396 polymorphism using data from N=1673 healthy subjects, which were collected in the context of the German multi-centre study ׳Genetics of Nicotine Dependence and Neurobiological Phenotypes׳.
|
26612384 |
2016 |
|
rs1044397
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Furthermore, we demonstrated a possible gene-gene interaction of CHRNA4 and CHRNB2 on ND in a dose-dependent manner: those smokers with CHRNA4 rs1044397 GG or GA genotypes along with CHRNB2 rs4845652 CC genotype are likely to demonstrate higher ND scores.
|
23037950 |
2013 |
|
rs1044397
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, rs755203 and rs1044397 in CHRNA4 might play a role in the pathophysiology of nicotine dependence in healthy controls in the Japanese population.
|
23553665 |
2013 |
|
rs1044396
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These findings suggest that CHRNA4 may be associated with smoking initiation and the C-G haplotype of rs1044396-rs1044397 might increase the vulnerability to nicotine dependence in Chinese male smokers.
|
21740768 |
2011 |
|
rs1044397
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These findings suggest that CHRNA4 may be associated with smoking initiation and the C-G haplotype of rs1044396-rs1044397 might increase the vulnerability to nicotine dependence in Chinese male smokers.
|
21740768 |
2011 |
|
rs1044396
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We investigated a synonymous single nucleotide polymorphisms (SNP): rs1044396, which has recently been associated with nicotine-dependence, plus two adjacent synonymous SNPs rs1044394 and rs1044393 in exon 5 of n = 47 unrelated healthy Caucasian subjects (age: 22.7 +/- 1.7 years; sex: n = 23 males; regular smokers: n = 19).
|
17613539 |
2007 |
|
rs1044396
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Univariate (single-marker) family-based association tests (FBATs) demonstrated that variant alleles at two SNPs, rs1044396 and rs1044397, in exon 5 of the CHRNA4 gene were significantly associated with a protective effect against nicotine addiction as either a dichotomized trait or a quantitative phenotype (i.e., age-adjusted FTND and RTQ scores), which was consistent with the results of the global haplotype FBAT.
|
15154117 |
2004 |
|
rs1044397
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Univariate (single-marker) family-based association tests (FBATs) demonstrated that variant alleles at two SNPs, rs1044396 and rs1044397, in exon 5 of the CHRNA4 gene were significantly associated with a protective effect against nicotine addiction as either a dichotomized trait or a quantitative phenotype (i.e., age-adjusted FTND and RTQ scores), which was consistent with the results of the global haplotype FBAT.
|
15154117 |
2004 |
|
rs2236196
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The consistent effect estimates across three independent cohorts elaborate on recently published functional studies of rs2236196 from the CHRNA4 3'-untranslated region and seem to converge with accumulating evidence to firmly implicate the variant G allele of this polymorphism in the intensification of nicotine dependence.
|
19290018 |
2009 |
|
rs2236196
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analysis of rs2273505-rs2273504-rs2236196 showed significant association after Bonferroni correction of a C-G-G haplotype (53.4%) with three adjusted ND measures in samples from the AA females.
|
15790597 |
2005 |
|
rs56175056
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that carriers of a rare missense variant (allele frequency=0.24%) within CHRNA4, encoding an R336C substitution, have greater risk of nicotine addiction than non-carriers as assessed by the Fagerstrom Test for Nicotine Dependence (P=1.2 × 10(-4)).
|
26952864 |
2016 |
|
rs755203
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, rs755203 and rs1044397 in CHRNA4 might play a role in the pathophysiology of nicotine dependence in healthy controls in the Japanese population.
|
23553665 |
2013 |
|
rs1044394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple testing, the association between rs1044394 and ND in the combined sample remained significant (P = 0.033).
|
21445957 |
2011 |
|
rs2273504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis of rs2273505-rs2273504-rs2236196 showed significant association after Bonferroni correction of a C-G-G haplotype (53.4%) with three adjusted ND measures in samples from the AA females.
|
15790597 |
2005 |
|
rs2273505
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis of rs2273505-rs2273504-rs2236196 showed significant association after Bonferroni correction of a C-G-G haplotype (53.4%) with three adjusted ND measures in samples from the AA females.
|
15790597 |
2005 |
|
rs3787137
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the AA samples, SNPs rs3787137 and rs2236196 are each significantly associated with at least two adjusted ND measures.
|
15790597 |
2005 |