rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
This study characterized the CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms in a Mexican population and its association with nicotine dependence, LC, and COPD.
|
29993116 |
2018 |
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Moreover, the TT genotype of the nicotinic acetylcholine receptor (nAChR) α3-subunit (CHRNA3) rs1051730 polymorphism has previously been associated with diminished PPI and nicotine dependence.
|
23604333 |
2013 |
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The CHRNA3 rs1051730 polymorphism has been associated to chronic obstructive pulmonary disease (COPD), lung cancer and nicotine dependence in case-control studies with high smoking exposure; however, its influence on lung function and COPD severity in the general population is largely unknown.
|
22441734 |
2012 |
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
These data confirm the effect of rs1051730 on nicotine dependence but failed to find any relationship with difficulty, willingness, and motivation to quit.
|
21511889 |
2011 |
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Genotypes for two SNPs in the CHRNA3/5 region (rs8034191, rs1051730) previously associated with nicotine dependence and COPD were analyzed for association to COPD and nicotine dependence phenotypes.
|
21232152 |
2011 |
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Cigarette consumption (P < .001) and nicotine dependence (P = .036) were the highest in the combined CYP2A6 normal metabolizers and CHRNA5-A3-B4 AA (tag single-nucleotide polymorphism rs1051730 G>A) risk group.
|
21747048 |
2011 |
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Using a cutoff point for the FTND score, the CHRNA3 Tyr215Tyr (rs1051730) polymorphism was also associated with nicotine dependence (p = 0.037 and p = 0.074 after correction for multiple testing).
|
20712524 |
2010 |
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
In the chr15q25.1 region spanning the nicotinic receptors CHRNA3 and CHRNA5, we identified multiple SNPs associated with CPD (p<10(-3)), including rs1051730, which has been associated with nicotine dependence, smoking intensity and lung cancer risk.
|
19247474 |
2009 |
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
A recent genome-wide association study demonstrated an association between a common polymorphism (rs1051730) in the nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) and both smoking quantity and nicotine dependence.
|
19429911 |
2009 |
rs1051730
|
|
T |
0.790 |
GeneticVariation |
GWASDB |
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.
|
18385739 |
2008 |