| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
A | 0.700 | CausalMutation | CLINVAR | Recently, two mutations in NRAS were reported to be associated with Noonan syndrome, T50I and G60E. | 21263000 | 2011 |
|||
|
T | 0.700 | CausalMutation | CLINVAR | A restricted spectrum of NRAS mutations causes Noonan syndrome. | 19966803 | 2010 |
|||
|
A | 0.700 | CausalMutation | CLINVAR | A restricted spectrum of NRAS mutations causes Noonan syndrome. | 19966803 | 2010 |
|||
|
A | 0.700 | CausalMutation | CLINVAR | RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia. | 18952898 | 2009 |
|||
|
T | 0.700 | CausalMutation | CLINVAR | Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. | 19047918 | 2009 |
|||
|
T | 0.700 | CausalMutation | CLINVAR | Hyperactive Ras in developmental disorders and cancer. | 17384584 | 2007 |
|||
|
T | 0.700 | CausalMutation | CLINVAR | Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies. | 16518851 | 2006 |
|||
|
A | 0.700 | CausalMutation | CLINVAR | Repressible transgenic model of NRAS oncogene-driven mast cell disease in the mouse. | 15831708 | 2005 |
|||
|
A | 0.700 | CausalMutation | CLINVAR | Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia. | 14982869 | 2004 |
|||
|
A | 0.700 | CausalMutation | CLINVAR | Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. | 15046639 | 2004 |
|||
|
T | 0.700 | CausalMutation | CLINVAR | Juvenile myelomonocytic leukemia and Noonan syndrome. | 10598665 | 2000 |