|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
FTO rs9939609 was associated with risk of obesity in additive model (p=0.031), recessive (p=0.033) and with altered WC in all models.
|
30713021 |
2020 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
FTO rs9939609 had an obvious and independent effect on obesity-related indices in early adolescents.
|
31402168 |
2020 |
|
rs79783591
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The MC4R p.Ile269Asn mutation may have emerged as a founder mutation in native Mexicans and is associated with childhood and adult obesity in the modern Mexican population.
|
31841602 |
2020 |
|
rs324420
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This may explain the greater vulnerability for addiction and obesity in individuals with C385A genetic variant and by extension, suggest that a D3 antagonism strategy in substance use disorders should consider FAAH C385A polymorphism.
|
31775159 |
2020 |
|
rs266729
|
|
|
0.050 |
GeneticVariation |
BEFREE |
ADIPOQ G rs266729 and TNF- 308 A allele are associated with obesity, MetS/NAFLD and insulin resistance.
|
31659105 |
2020 |
|
rs3751723
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The odds ratios (OR) showed that IRX3 rs3751723 was associated with risk of obesity in additive model (p=0.017), recessive model (p=0.016) and with high BF% in all models.
|
30713021 |
2020 |
|
rs11554825
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We noticed an association between obesity and variations in TGR5 rs11554825 SNP.
|
31812910 |
2020 |
|
rs1333048
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings indicate that there are significant associations between AA genotype of rs1333048 SNP and general and central obesity, and significant interaction between alleles of this SNP and major dietary patterns on the odds of general obesity, BFP, waist circumference, BMI, WHtR and hs-Crp.
|
30600348 |
2020 |
|
rs3847987
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Allele C of rs3847987 was risk factors for obesity (P = 0.006).
|
31813936 |
2020 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
FTO genotypes associated with risk for obesity and loss of control of eating, specifically rs1421085, may interact with insecure attachment in a way that may exacerbate binge eating among women with BED.
|
30822753 |
2019 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
FTO SNPs rs1421085</span> and rs9939609 affect genetic susceptibility for obesity only in girls, whereas, SNP rs8057044 and CNV are associated with overweight status only in boys.
|
30537186 |
2019 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results suggested that FTO rs9939609, MC4R rs12970134, and MC4R rs17782313 are strongly associated with obesity.
|
30896429 |
2019 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, BDNF rs6265 and MC4R rs17782313 showed gender-dependent associations with decreased risk of having low HDL-C in males and increased risk of having abdominal obesity in females, respectively.
|
31502573 |
2019 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study pointed out the role of MC4R rs17782313 and ENPP1 rs1044498 genotypes in obesity determinisms in mothers and their newborns in correlation with BMI, MUAC, TST and bioimpedance parameters.
|
31350533 |
2019 |
|
rs8050136
|
|
|
0.900 |
GeneticVariation |
BEFREE |
An unweighted genetic risk score (GRS) was calculated for two <i>FTO</i> single-nucleotide polymorphisms (rs8050136 and rs2388405) by summation of the number of risk alleles for obesity.
|
31516636 |
2019 |
|
rs10938397
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Genome-wide association studies have found an obesity-related single-nucleotide polymorphism rs10938397 near the glucosamine-6-phosphate deaminase 2 gene (<i>GNPDA2</i>) encoding, an enzyme that catalyzes the deamination of the glucosamine-6-phosphate involved in the hexosamine signaling pathway, but the molecular mechanisms underlying the missing link between <i>GNPDA2</i> and obesity remain elusive.
|
31467530 |
2019 |
|
rs1412239
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Genome-wide association studies (GWASs) showed that three single nucleotide polymorphisms (SNPs; rs10968576, rs1412239, and rs824248) in the leucine-rich repeat and Ig domain containing 2 (LINGO2) were associated with obesity or type 2 diabetes (T2D).
|
30426492 |
2019 |
|
rs1516725
|
|
|
0.810 |
GeneticVariation |
BEFREE |
While the majority of these were located in intergenic regions or in a locus on chromosome 16 near and in the NPIPL1 and SH2B1 genes (best SNP: rs4788101, p = 2.1E-24), five were located in the ETV5 gene (best SNP: rs1516725, p = 1E-24), which was previously associated with both BD and obesity, and one in the RPGRIP1L gene (rs1477199, p = 5.7E-09), which was also included in the Signaling by Hedgehog pathway.
|
31754094 |
2019 |
|
rs1800437
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies identified a single nucleotide variant (SNV) in the GIPR encoding gene (GIPR), rs1800437, that is associated with obesity and insulin resistance.
|
30784161 |
2019 |
|
rs7185735
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We focused on rs7185735 and rs9939609, 2 common single nucleotide polymorphisms of the fat mass and obesity-associated (FTO) gene reported to be associated with obesity.
|
29334686 |
2019 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Thus, understanding the relationship between ADRB3 Trp64Arg substitution and fat preference will be valuable for obesity prevention.
|
31353327 |
2019 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We focused on rs7185735 and rs9939609, 2 common single nucleotide polymorphisms of the fat mass and obesity-associated (FTO) gene reported to be associated with obesity.
|
29334686 |
2019 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Findings of the present study highlight the association between FTO rs9939609 and obesity or body fat indices in girls but not in boys.
|
31444941 |
2019 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The FTO gene polymorphism rs9939609 is associated with obesity and disability in multiple sclerosis patients.
|
31836807 |
2019 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Of interest, a markedly lower frequency of the FTO rs9939609 obesity risk A-allele was found in BED patients (0.290) in relation to the control group (0.402).
|
30677719 |
2019 |