|
rs699
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We studied the effects of the angiotensinogen M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of HTA and to evaluate the relationship between these polymorphisms and obesity.
|
21779803 |
2012 |
|
rs1267969615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We studied the effects of the angiotensinogen M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of HTA and to evaluate the relationship between these polymorphisms and obesity.
|
21779803 |
2012 |
|
rs6235
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the association of the PCSK1 single-nucleotide polymorphism (SNP) rs6235 (encoding an S690T substitution) with essential hypertension (EH), obesity and related traits in the Han Chinese population.
|
22592666 |
2012 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the C825T polymorphism in relation to blood pressure, obesity and intermediate phenotypes in a Caucasian population.
|
12658019 |
2003 |
|
rs10911021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We sought to determine whether GLUL rs10911021 is associated prospectively with adjudicated cardiovascular composite end points among overweight/obese individuals with T2D and whether a lifestyle intervention resulting in weight loss could diminish this association.
|
26395743 |
2016 |
|
rs1805094
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We searched electronic databases, including population-based studies that investigated the association between LEPR variants Q223R, K109R and K656N and obesity- related phenotypes in healthy, unrelated subjects.
|
22028824 |
2011 |
|
rs1137100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We searched electronic databases, including population-based studies that investigated the association between LEPR variants Q223R, K109R and K656N and obesity- related phenotypes in healthy, unrelated subjects.
|
22028824 |
2011 |
|
rs149540566
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We screened the POMC gene in 538 patients with severe, early-onset obesity and identified five unrelated probands who were heterozygous for a rare missense variant in the region encoding beta-MSH, Tyr221Cys.
|
16459314 |
2006 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We scanned for the polymorphism of Arg389Gly (rs1801253) in ADRB1 and Trp64Arg (rs4994) in ADRB3 genes in Saudi population to determine association, if any, of these polymorphisms with obesity and related disorders.
|
29587766 |
2018 |
|
rs397517892
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We resequenced the coding region, flanking intronic, and proximal promoter regions of the lamin a/c gene in 43 women with PCOS with evidence of upper-body obesity (waist circumference >88 cm) and identified 56 variants, two of which were nonsynonymous substitutions (lmna11 exon1 E98D; lmna24 exon 7 R455C).
|
19401371 |
2009 |
|
rs1800497
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We report a potential association between rs1800497 (linked to changes in brain dopamine receptor levels) and central obesity in a young Mexican-American population.
|
22056417 |
2011 |
|
rs375095163
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We present the case report of a 2 year old boy with early onset extreme obesity (body mass index (BMI) 34.2 kg/m²; body mass index standard deviation score (BMI-SDS) 5.4) who is heterozygous for a non-conservative functionally relevant melanocortin MC(4)receptor mutation (Glu308Lys) and who also showed severe symptoms of attention deficit/hyperactivity disorder (ADHD).
|
21211528 |
2011 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We performed molecular scanning of the human type 2 deiodinase (DIO2) gene and evaluated a novel variant for associations with obesity and insulin resistance, assessing both the main effect and interaction with the Trp64Arg beta-3--adrenergic receptor (ADRB3) variant.
|
11872697 |
2002 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We performed a cross-sectional study in a sample that was enriched for obesity and included 20 higher-risk participants with the AA (risk) genotype at the rs9939609 locus of FTO and 94 lower-risk participants with either the AT or TT genotype.
|
29529147 |
2018 |
|
rs1298635718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We obtained higher serum leptin levels in infants with the GG genotype for Lepr A668G, with haplotype GG/GG for Lep G2548A/A19G, and with GG/GG-GG (LepG2548A/A19G-Lepr A668G); thus, it seems that the genotype GG could be a protector against obesity development in infancy and adulthood.
|
28628399 |
2017 |
|
rs1487493809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We obtained higher serum leptin levels in infants with the GG genotype for Lepr A668G, with haplotype GG/GG for Lep G2548A/A19G, and with GG/GG-GG (LepG2548A/A19G-Lepr A668G); thus, it seems that the genotype GG could be a protector against obesity development in infancy and adulthood.
|
28628399 |
2017 |
|
rs1137101
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We obtained higher serum leptin levels in infants with the GG genotype for Lepr A668G, with haplotype GG/GG for Lep G2548A/A19G, and with GG/GG-GG (LepG2548A/A19G-Lepr A668G); thus, it seems that the genotype GG could be a protector against obesity development in infancy and adulthood.
|
28628399 |
2017 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We observed an interaction between the consumption of SFA (percentage of total energy) and PUFA:SFA ratio and obesity risk linked to the rs9939609 SNP of the FTO gene.
|
21798115 |
2012 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We observed an association between the common FTO rs9939609 polymorphism and increased BMI (overweight/obesity) in Kuwaiti adults, which is consistent with previous research in other populations.
|
29402776 |
2018 |
|
rs7566605
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We observed a significant association of rs7566605 polymorphism with BMI related obesity in Uyghurs with an odds ratio of 1.47 (95% CI 1.11-1.95, P=0.006) under a dominant model (CC+GC versus GG).
|
18514965 |
2008 |
|
rs28954113
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We now describe two siblings, a 9-year-old girl and a 6-year-old boy with severe early-onset obesity and hyperphagia, both homozygous for a c.309C>A substitution in the leptin gene leading to a p.N103K amino acid exchange in the protein and detectable circulating levels of leptin.
|
26186301 |
2015 |
|
rs11554825
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We noticed an association between obesity and variations in TGR5 rs11554825 SNP.
|
31812910 |
2020 |
|
rs11624704
|
|
|
0.800 |
GeneticVariation |
GWASDB |
We next examined obesity-related quantitative traits (such as total body weight, waist circumference and waist to hip ratio), and detected genome-wide significant signals between waist to hip ratio and NRXN3 (rs11624704, P = 2.67 × 10(-9)), previously associated with body weight and fat distribution.
|
21552555 |
2011 |
|
rs11624704
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
We next examined obesity-related quantitative traits (such as total body weight, waist circumference and waist to hip ratio), and detected genome-wide significant signals between waist to hip ratio and NRXN3 (rs11624704, P = 2.67 × 10(-9)), previously associated with body weight and fat distribution.
|
21552555 |
2011 |
|
rs1057231
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We located and investigated such SNP (rs1057231) in relation to the FSTL1 protein level, obesity status, and other body composition parameters.
|
30595761 |
2018 |