Gene: SIRT1 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7069102
rs7069102
SIRT1
0.020 GeneticVariation BEFREE The allele frequencies of rs7895833 and rs7069102</span>, which are different from Caucasians, might explain why Japanese show less marked obesity compared with Caucasians. 21575918

2011
dbSNP: rs7069102
rs7069102
SIRT1
0.020 GeneticVariation BEFREE The variant C-allele of rs7069102 reduced obesity risk with an OR of 0.74 (P = 0.025; 95% CI 0.57-0.96) under a dominant model. 18820948

2008
dbSNP: rs2273773
rs2273773
SIRT1
0.010 GeneticVariation BEFREE Thus, the A allele of rs7895833, G allele of rs7069102, and T allele of rs2273773 carried a high risk for obesity in men. 21575918

2011
dbSNP: rs1467568
rs1467568
SIRT1
0.010 GeneticVariation BEFREE Carriers of these alleles had 13-18% decreased risk of obesity (for rs7895833 in the Rotterdam Study: odds ratio 0.79 [95% CI 0.67-0.94], P = 0.007; in the ERF study: 0.93 [0.73-1.19], P = 0.37; and in the studies combined 0.87 [0.77-0.97], P = 0.02; for rs1467568 in the Rotterdam Study: 0.80 [0.68-0.94], P = 0.007; in the ERF study: 0.85 [0.72-0.99], P = 0.04; and in the studies combined: 0.82 [0.73-0.92], P = 0.0009). 19741164

2009