rs660339
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In our case-control study we were not able to demonstrate any association between UCP polymorphisms and obesity in T2DM patients; however, in the meta-analysis we detected a significant association of UCP2 -866G/A, Ins/Del, Ala55Val and UCP3 -55C/T polymorphisms with obesity.
|
24752406 |
2014 |
rs660339
|
|
|
0.080 |
GeneticVariation |
BEFREE |
And our results did not support the association between UCP2 Ala55Val, UCP3 -55C/T polymorphisms and obesity in the populations investigated.
|
23560041 |
2013 |
rs660339
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We examined the association of commonly observed UCP2 G(-866)A (rs659366) and Ala55Val (C > T) (rs660339) single nucleotide polymorphisms (SNPs) with obesity, high fasting plasma glucose, and serum lipids in a Balinese population.
|
22533685 |
2012 |
rs660339
|
|
|
0.080 |
GeneticVariation |
BEFREE |
UCP2 A55V variant might predispose to obesity and Val55 allele to confer population-attributable risk for 9.5% of obese disorders and increase insulin concentrations.
|
17502873 |
2007 |
rs660339
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Ala55Val may play a crucial role in obesity development and weight loss after LAGB.
|
17894153 |
2007 |
rs660339
|
|
|
0.080 |
GeneticVariation |
BEFREE |
No association was found between the Ala55Val SNP and obesity and blood levels of insulin, glucose, and lipids as well as blood pressure and circulating hormones.
|
12385772 |
2002 |
rs660339
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These results indicate that the Ala55 --> Val and Ala232 --> Thr variants of UCP2 do not play an important role in the pathogenesis of NIDDM or obesity in the Japanese population.
|
9709950 |
1998 |
rs660339
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The allelic frequency of the A/V55 variant was 48.3% (95% CI: 42.5-54.1%) among 144 subjects with juvenile onset obesity, 45.6% (40.5-50.7%) among 182 subjects randomly selected at the draft board examination, and 45.5% (37.1-53.9%) among lean control subjects selected from the same study cohort.
|
9349606 |
1997 |
rs659366
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To test this hypothesis, we investigated the interaction between tagging polymorphisms in the UCP2 gene (rs2306819, rs599277 and rs659366), alcohol intake and obesity traits such as BMI and waist circumference (WC) on alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) in a large meta-analysis of data sets from three populations (n=20 242).
|
26526553 |
2015 |
rs659366
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We genotyped UCP2 rs659366 in a total of 17 636 Danish individuals and established case-control studies of obese and non-obese subjects and of type 2 diabetic and glucose-tolerant subjects.
|
22349573 |
2013 |
rs659366
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Furthermore, rs659366 polymorphism was associated with the risk of abdominal obesity (P= 0·04: OR = 1·3; CI = 1·01-1·67).
|
21883184 |
2012 |
rs659366
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We examined the association of commonly observed UCP2 G(-866)A (rs659366) and Ala55Val (C > T) (rs660339) single nucleotide polymorphisms (SNPs) with obesity, high fasting plasma glucose, and serum lipids in a Balinese population.
|
22533685 |
2012 |
rs659366
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We found that the individual polymorphisms were not associated with obesity, but the (-866G; rs659366)-(Del; 45bp)-(-55T; rs1800849) haplotype was significantly associated with obesity and its presence in the control group increased about nine times the insulin resistance risk.
|
17870627 |
2007 |
rs200027152
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicate that the Ala55 --> Val and Ala232 --> Thr variants of UCP2 do not play an important role in the pathogenesis of NIDDM or obesity in the Japanese population.
|
9709950 |
1998 |