|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Thus, understanding the relationship between ADRB3 Trp64Arg substitution and fat preference will be valuable for obesity prevention.
|
31353327 |
2019 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We scanned for the polymorphism of Arg389Gly (rs1801253) in ADRB1 and Trp64Arg (rs4994) in ADRB3 genes in Saudi population to determine association, if any, of these polymorphisms with obesity and related disorders.
|
29587766 |
2018 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We systemically evaluated the association of β3-adrenergic receptor(ADRB3)rs4994 and type 2 diabetes(T2DM) by pooling all of the case-control studies reported, and also elucidated the association according to the ethnicity and obesity of the subjects.
|
28521197 |
2017 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The beta-3 adrenergic receptor (β3-AR) Trp64Arg and uncoupling protein 1 (UCP1) -3826 A>G polymorphisms have been reported to be associated with obesity and/or lipid metabolism in some populations.
|
25928572 |
2015 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
W64R polymorphism of the β-3AR gene is not associated with obesity and waist-to-hip ratio in Turkish children.
|
25800470 |
2015 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
UCP1 -3826A/G and ADRB3 Trp64Arg polymorphisms may have a combined effect in the modulation of overweight/obesity and HDL-C levels in type 2 diabetes mellitus (T2DM) Caucasian-Brazilian patients.
|
24138564 |
2014 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphisms (SNPs) of the above genes, such as GNB3-C825T, ADRB3-Trp64Arg, UCP2-3'UTR 45 bp del/ins, and PPARγ-Pro12Ala, are associated with obesity and body mass index.
|
24827746 |
2014 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Among 709 overweight/obese and 637 normal weight children (age 6-17 years), anthropometric measurements were carried out and genotyping for the following gene polymorphisms: β3 -adrenoreceptor Trp64Arg, uncoupling protein (UCP) -1 -3826 A/G, UCP-2 -866 G/A and exon 8 del/ins, UCP-3 -55 C/T and peroxisome proliferator-activated receptor-γ Pro12Ala.
|
23432701 |
2013 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The β3-adrenoceptor (ADRB3) gene Trp64Arg polymorphism has been shown to be associated with obesity as well as type 2 diabetes and cardiovascular disease.
|
22609474 |
2012 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was an association between Trp64Arg и Arg64Arg genotypes and higher BMI, WC and obesity frequency (p < 0.00009), AO (p < 0.01), type 2 diabetes mellitus (DM) (p < 0.005) and lower high density cholesterol (HDL-C) level (p < 0.03).
|
21992420 |
2011 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Although each polymorphism of β3AR Trp64Arg, β2AR Arg16Gly and UCP1 -3826A>G is known to be associated with obesity, the interaction among these polymorphisms is not fully understood.
|
21959333 |
2011 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
It has been shown that the β3-adrenergic receptor (β3-AR) gene Trp64Arg mutation was closely related to obesity and insulin resistance, and may be related to the prevalence of metabolic syndrome (MS).
|
21034552 |
2010 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Trp64Arg does not confer an increased risk of obesity among Danes.
|
18249022 |
2008 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A missense mutation of the human ADRB3 gene replacing tryptophan with arginine at codon 64 (Trp64Arg) has been related to obesity, insulin resistance, earlier onset of noninsulin-dependent diabetes mellitus and hypertension.
|
18088254 |
2008 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Some studies indicate that the Trp64Arg polymorphism in the gene encoding the beta(3)-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus.
|
18335327 |
2008 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Association of Trp64Arg polymorphism of beta3-adrenergic receptor with insulin resistance in Polish children with obesity.
|
18422027 |
2008 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The substitution of tryptophan 64 with arginine (Trp64Arg) polymorphism (Arg variant) of the beta(3)-adrenergic receptor (ADRB3) has been associated with obesity.
|
17626108 |
2007 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
ADRB3 Trp64Arg genotype, measures of weight including body mass index (BMI), weight gain (weight 5 years before diagnosis compared with weight at 30 months after diagnosis), obesity (BMI> or =30 kg/m(2)), waist/hip circumference and visceral or subcutaneous fat were determined by magnetic resonance imaging.
|
17264845 |
2007 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The Trp64Arg polymorphism of ADRB3 seems to not be related to obesity in postmenopausal women.
|
17852419 |
2007 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Beta3AR Trp64Arg and PPARgamma2 Pro12Ala polymorphisms might be associated with insulin resistance and obesity, and there might be slight synergistic effects between this two gene loci, and further studies are necessary to confirm this finding.
|
17624182 |
2007 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated with obesity in middle-aged Korean women, but it is difficult to suggest the prominent association of the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene with prevalence of abdominal obesity or dyslipidemia in Korean middle-aged women.
|
17087055 |
2006 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Thus, heterozygosity for the Trp64Arg variant is unlikely to increase the risk of obesity, insulin resistance or type 2 diabetes.
|
16634992 |
2006 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The Trp64Arg polymorphism of ADRB3 warrants consideration, along with other polymorphisms involved in the development of obesity, for tailor-made prevention of obesity.
|
16276029 |
2005 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We have investigated whether the Trp64Arg polymorphism is associated with the manifestation of CAD or one of its important risk factors, such as obesity, diabetes mellitus, elevated cholesterol and triglyceride levels, or hypertension in the Arab population.
|
16715838 |
2005 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The frequency of the Trp64Arg polymorphism was similar in healthy women and PCOS women, and a possible interaction between the effect of this variant and obesity in PCOS could not be demonstrated.
|
15670186 |
2005 |