rs4680
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Previous research shows that OCD is associated with serotonin-related polymorphisms (5-HTTLPR coded as triallelic and HTR2A rs6311/rs6313) and, in males, a polymorphism involved in catecholamine modulation; COMT (rs4680).
|
26616111 |
2016 |
rs4680
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A sample of 199 patients with OCD and 200 healthy individuals was genotyped for -287A > G (rs2075507) and Val158Met (rs4680) single nucleotide polymorphisms (SNPs) by TaqMan(®) or restriction mapping.
|
26687156 |
2016 |
rs4680
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The present case-control/pharmacogenetic study did not provide clear evidence that the COMT Val158Met polymorphism is a predictor of OCD or of OCD patients' clinical responses.
|
26010653 |
2015 |
rs4680
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Therefore, the purpose of our study was to assess COMT activity in OCD by measuring plasma levels of 3-O-methyl-dopa (3-OMD), which result from the methylation of levodopa by COMT, and to investigate the relationship between 3-OMD levels and the V158M polymorphism.
|
19676096 |
2010 |
rs4680
|
|
|
0.090 |
GeneticVariation |
BEFREE |
There was a trend for an association of the COMT 158Met allele with OCD i</span>n males, and an interaction between the COMT Val158Met genotype and sex on the somatic and sensory phenomena symptom dimension, with females showing lower scores.
|
19521967 |
2010 |
rs4680
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A haplotype composed of three SNPs [rs2097603; rs4680 (158Val/Met); rs165599] representing the major linkage disequilibrium blocks in COMT and previously implicated in functional variation, was found to be associated with ADHD and OCD in 22q11.2DS individuals.
|
17949513 |
2008 |
rs4680
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significantly more common in the OCD hoarding group, with a preponderance of low activity alleles, compared with nonhoarding patients and controls.
|
16187774 |
2005 |
rs4680
|
|
|
0.090 |
GeneticVariation |
BEFREE |
These results do not support the hypothesis that the COMT Val158Met gene polymorphism is associated with liability to schizophrenia-OCD.
|
16043283 |
2005 |
rs4680
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This polymorphism (valine to methionine at codon 158) has been previously reported to influence the activity of COMT by three to four-fold and has recently been reported to be associated with OCD.1 We tested for linkage using an autosomal dominant model with reduced penetrance and non-parametric methods.
|
10523824 |
1999 |
rs2075507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A sample of 199 patients with OCD and 200 healthy individuals was genotyped for -287A > G (rs2075507) and Val158Met (rs4680) single nucleotide polymorphisms (SNPs) by TaqMan(®) or restriction mapping.
|
26687156 |
2016 |
rs165599
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A haplotype composed of three SNPs [rs2097603; rs4680 (158Val/Met); rs165599] representing the major linkage disequilibrium blocks in COMT and previously implicated in functional variation, was found to be associated with ADHD and OCD in 22q11.2DS individuals.
|
17949513 |
2008 |
rs2097603
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A haplotype composed of three SNPs [rs2097603; rs4680 (158Val/Met); rs165599] representing the major linkage disequilibrium blocks in COMT and previously implicated in functional variation, was found to be associated with ADHD and OCD in 22q11.2DS individuals.
|
17949513 |
2008 |