|
rs301430
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In the present study, we aimed to assess the association of SLC1A1 polymorphisms (rs301430, rs2228622 and rs3780413) with OCD and its clinical characteristics, as well as the importance of these SNPs in the response of OCD patients to SSRI pharmacotherapy.
|
30315580 |
2019 |
|
rs301430
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The C-T-G haplotype at rs301430-rs301434-rs3087879 of SLC1A1 was significantly associated with higher PD scores after adjusted for age, sex, and OCD status.
|
29304071 |
2018 |
|
rs301430
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This case-control study enrolled 578 obsessive-compulsive disorder (OCD) patients and 649 controls and genotyped rs10491734, rs2228622, rs301430 and rs301443 to replicate association of the SLC1A1 gene with OCD in ethnic Han Chinese.
|
23411042 |
2013 |
|
rs301430
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Two haplotypes at 3 SNPs, rs3087879, rs301430, and rs7858819, were significantly associated with OCD after multiple-testing correction and contained 2 SNPs associated with expression levels.
|
19349310 |
2009 |
|
rs301430
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Additionally, an rs301430-rs301979 haplotype identified for OCD was investigated.
|
19360657 |
2008 |
|
rs301430
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Association between OCD and the three-marker haplotype rs12682807/ rs2072657/ rs301430, with overtransmission of A/T/T, was observed in both genders combined (global P = 0.0015) and in males (global P = 0.0031).
|
17894418 |
2007 |
|
rs301434
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The A-A-G (rs301434-rs3780412-rs301443) haplotype was twice as common in OCD as in controls (P = 0.02).
|
30661718 |
2019 |
|
rs301434
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The C-T-G haplotype at rs301430-rs301434-rs3087879 of SLC1A1 was significantly associated with higher PD scores after adjusted for age, sex, and OCD status.
|
29304071 |
2018 |
|
rs301434
|
|
|
0.040 |
GeneticVariation |
BEFREE |
To test for association between SLC1A1 and autism, we typed three single nucleotide polymorphisms (SNPs, rs301430, rs301979, rs301434) previously associated with OCD in 86 strictly defined trios with autism.
|
19360657 |
2008 |
|
rs301434
|
|
|
0.040 |
GeneticVariation |
BEFREE |
After correction for multiple comparisons, 2 variants, rs301434 (chi 2 = 12.04; P = .006) and rs301435 (chi 2 = 9.24; P = .03), located within a single haplotype block were found to be associated with transmission of OCD.
|
16818866 |
2006 |
|
rs2228622
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the present study, we aimed to assess the association of SLC1A1 polymorphisms (rs301430, rs2228622 and rs3780413) with OCD and its clinical characteristics, as well as the importance of these SNPs in the response of OCD patients to SSRI pharmacotherapy.
|
30315580 |
2019 |
|
rs2228622
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This case-control study enrolled 578 obsessive-compulsive disorder (OCD) patients and 649 controls and genotyped rs10491734, rs2228622, rs301430 and rs301443 to replicate association of the SLC1A1 gene with OCD in ethnic Han Chinese.
|
23411042 |
2013 |
|
rs2228622
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Single-marker associations with OCD in the region (rs3780412 and rs2228622) demonstrated modest significance (permuted P = 0.045).
|
17894418 |
2007 |
|
rs3780412
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The A-A-G (rs301434-rs3780412-rs301443) haplotype was twice as common in OCD as in controls (P = 0.02).
|
30661718 |
2019 |
|
rs3087879
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The C-T-G haplotype at rs301430-rs301434-rs3087879 of SLC1A1 was significantly associated with higher PD scores after adjusted for age, sex, and OCD status.
|
29304071 |
2018 |
|
rs3087879
|
|
|
0.020 |
GeneticVariation |
BEFREE |
For the most strongly associated SNP (rs3087879), one copy of the risk allele increased the probability of higher treatment resistance (odds ratio=2.42; 95% confidence interval=1.39-4.21; P=0.0018), but only in OCD patients without life stress at onset of the disorder.
|
22776887 |
2013 |
|
rs3780412
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single-marker associations with OCD in the region (rs3780412 and rs2228622) demonstrated modest significance (permuted P = 0.045).
|
17894418 |
2007 |
|
rs3780413
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we aimed to assess the association of SLC1A1 polymorphisms (rs301430, rs2228622 and rs3780413) with OCD and its clinical characteristics, as well as the importance of these SNPs in the response of OCD patients to SSRI pharmacotherapy.
|
30315580 |
2019 |
|
rs12682807
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Secondary analyses of male-affecteds only (N = 358 trios and 133 cases) demonstrated modest association between OCD and a different SNP (rs12682807; uncorrected P = 0.012; non-significant corrected P).
|
23606572 |
2013 |
|
rs7858819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two haplotypes at 3 SNPs, rs3087879, rs301430, and rs7858819, were significantly associated with OCD after multiple-testing correction and contained 2 SNPs associated with expression levels.
|
19349310 |
2009 |
|
rs301979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, an rs301430-rs301979 haplotype identified for OCD was investigated.
|
19360657 |
2008 |
|
rs301435
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple comparisons, 2 variants, rs301434 (chi 2 = 12.04; P = .006) and rs301435 (chi 2 = 9.24; P = .03), located within a single haplotype block were found to be associated with transmission of OCD.
|
16818866 |
2006 |