|
rs12901499
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The current meta-analysis revealed that the G variant of SMAD3 rs12901499 polymorphism increased the risk of OA in Caucasians.
|
30208919 |
2018 |
|
rs12901499
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, SMAD3 rs12901499 polymorphism may be involved in the development of knee OA.
|
29315792 |
2018 |
|
rs12901499
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Stratification analysis of ethnicity found that rs12901499 polymorphism increased the risk of osteoarthritis</span> among</span> both Asians and Caucasians [G vs A: Asians, OR and 95%CI, 1.34(1.07, 1.69), <i>P</i>=0.012; Caucasians, OR and 95%CI, 1.21(1.13, 1.29), <i>P</i><0.001].
|
29764993 |
2018 |
|
rs12901499
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The association between rs12901499 polymorphism in SMAD3 gene and risk of osteoarthritis: a meta-analysis.
|
29805262 |
2018 |
|
rs12901071
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found robustly replicating evidence for association with OA at rs12901071 (OR 1.08 95% CI 1.05-1.11, Pmeta=3.12 × 10-10), an intronic variant in the SMAD3 gene, which is known to play a role in bone remodeling and cartilage maintenance.
|
28934396 |
2017 |
|
rs12102171
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CC and CT+TT and TT and TG+GG genotypes of SMAD3 rs12102171 and rs2289263 polymorphisms together with BMI may be susceptible factors to OA, and interactions there between can possibly confer risk to OA.
|
26261637 |
2015 |
|
rs2289263
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CC and CT+TT and TT and TG+GG genotypes of SMAD3 rs12102171 and rs2289263 polymorphisms together with BMI may be susceptible factors to OA, and interactions there between can possibly confer risk to OA.
|
26261637 |
2015 |
|
rs6494629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Gene-gene interactions between Smad3 rs6494629T/C and TIMP3 rs715572G/A polymorphisms may play more important protective roles in knee OA.
|
26068512 |
2015 |
|
rs12595334
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This G allele was underrepresented in osteoarthritis cases vs controls (P = 0.027, odds ratio = 0.921). rs8031440 is in perfect linkage disequilibrium with five other SMAD3 3'UTR SNPs and our luciferase analysis identified rs3743342 and rs12595334 as being functional.
|
24583347 |
2014 |
|
rs3743342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This G allele was underrepresented in osteoarthritis cases vs controls (P = 0.027, odds ratio = 0.921). rs8031440 is in perfect linkage disequilibrium with five other SMAD3 3'UTR SNPs and our luciferase analysis identified rs3743342 and rs12595334 as being functional.
|
24583347 |
2014 |
|
rs8031440
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This G allele was underrepresented in osteoarthritis cases vs controls (P = 0.027, odds ratio = 0.921). rs8031440 is in perfect linkage disequilibrium with five other SMAD3 3'UTR SNPs and our luciferase analysis identified rs3743342 and rs12595334 as being functional.
|
24583347 |
2014 |