|
rs4252548
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs6976
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs9350591
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs117018441
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In addition, using a recessive model, we confirm an association between hip osteoarthritis and a variant of CHADL<sup>1</sup> (rs117018441, P = 1.8 × 10<sup>-25</sup>, OR = 5.9).
|
30374069 |
2018 |
|
rs117018441
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
In addition, using a recessive model, we confirm an association between hip osteoarthritis and a variant of CHADL<sup>1</sup> (rs117018441, P = 1.8 × 10<sup>-25</sup>, OR = 5.9).
|
30374069 |
2018 |
|
rs143083812
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Two associations are between rare or low-frequency missense variants and hip osteoarthritis, affecting the genes SMO (rs143083812, frequency 0.11%, odds ratio (OR) = 2.8, P = 7.9 × 10<sup>-12</sup>, p.Arg173Cys) and IL11 (rs4252548, frequency 2.08%, OR = 1.30, P = 2.1 × 10<sup>-11</sup>, p.Arg112His).
|
30374069 |
2018 |
|
rs143083812
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Two associations are between rare or low-frequency missense variants and hip osteoarthritis, affecting the genes SMO (rs143083812, frequency 0.11%, odds ratio (OR) = 2.8, P = 7.9 × 10<sup>-12</sup>, p.Arg173Cys) and IL11 (rs4252548, frequency 2.08%, OR = 1.30, P = 2.1 × 10<sup>-11</sup>, p.Arg112His).
|
30374069 |
2018 |
|
rs4252548
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Two associations are between rare or low-frequency missense variants and hip osteoarthritis, affecting the genes SMO (rs143083812, frequency 0.11%, odds ratio (OR) = 2.8, P = 7.9 × 10<sup>-12</sup>, p.Arg173Cys) and IL11 (rs4252548, frequency 2.08%, OR = 1.30, P = 2.1 × 10<sup>-11</sup>, p.Arg112His).
|
30374069 |
2018 |
|
rs4252548
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Two associations are between rare or low-frequency missense variants and hip osteoarthritis, affecting the genes SMO (rs143083812, frequency 0.11%, odds ratio (OR) = 2.8, P = 7.9 × 10<sup>-12</sup>, p.Arg173Cys) and IL11 (rs4252548, frequency 2.08%, OR = 1.30, P = 2.1 × 10<sup>-11</sup>, p.Arg112His).
|
30374069 |
2018 |
|
rs6976
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.
|
30374069 |
2018 |
|
rs9350591
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.
|
30374069 |
2018 |
|
rs6976
|
|
|
0.710 |
GeneticVariation |
BEFREE |
These de novo findings suggest that rs4836732, rs6976, and rs5009270 may contribute to hip OA susceptibility by altering proximal femur shape.
|
25939412 |
2015 |
|
rs9350591
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The arcOGEN genome-wide association study reported the rs9350591 C/T single nucleotide polymorphism (SNP) as marking a region on chromosome 6q14.1 that is associated with hip osteoarthritis (OA) in Europeans, with an odds ratio (OR) of 1.18 and a p-value of 2.42 × 10(-9). rs9350591 is an intergenic SNP surrounded by seven genes within 1 Mb.
|
26346884 |
2015 |
|
rs10492367
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs10758594
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs10896015
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs10948172
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs11059094
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs11105466
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs11456119
|
|
TA |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs115740542
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs11583641
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs11732213
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs11997261
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs12040949
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |