Gene: P2RX7 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28360457
rs28360457
P2RX7 ; LOC105370032
0.020 GeneticVariation BEFREE We found that the rate of bone loss was clearly associated with the Arg307Gln amino acid substitution such that individuals heterozygous for this polymorphism had a 40% increased rate of bone loss. 22274585

2012
dbSNP: rs28360457
rs28360457
P2RX7 ; LOC105370032
0.020 GeneticVariation BEFREE This is the first report that describes association of the c.946A (p.Arg307Gln) LOF SNP with low LS-BMD, and that other LOF SNPs, which result in reduced or no function of the P2X7 receptor, may contribute to accelerated bone loss. 22234152

2012
dbSNP: rs1653624
rs1653624
P2RX7 ; LOC105370032
0.010 GeneticVariation BEFREE Furthermore, individuals carrying the Ile568Asn variant allele had increased bone loss. 22274585

2012
dbSNP: rs2230912
rs2230912
P2RX7 ; LOC105370032
0.010 GeneticVariation BEFREE In contrast, the Gln460Arg polymorphism was associated with protection against bone loss. 22274585

2012