Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1064794292
rs1064794292
CDKN2A
0.700 GeneticVariation UNIPROT

dbSNP: rs121913385
rs121913385
CDKN2A
0.700 GeneticVariation UNIPROT

dbSNP: rs1799939
rs1799939
RET
0.010 GeneticVariation BEFREE The G691S RET polymorphism was also detected in human pancreatic tumors and represented a somatic mutation in some patients. 16357163

2005
dbSNP: rs1444669684
rs1444669684
CDKN2A ; CDKN2B-AS1
0.030 GeneticVariation BEFREE We show here that concomitant expression of Kras(G12D) and haploinsufficiency of the Smad4/Dpc4 tumor suppressor gene engenders a distinct class of pancreatic tumors, mucinous cystic neoplasms (MCNs), which culminate in invasive ductal adenocarcinomas. 17349581

2007
dbSNP: rs762846821
rs762846821
TP53
0.010 GeneticVariation BEFREE We show here that concomitant expression of Kras(G12D) and haploinsufficiency of the Smad4/Dpc4 tumor suppressor gene engenders a distinct class of pancreatic tumors, mucinous cystic neoplasms (MCNs), which culminate in invasive ductal adenocarcinomas. 17349581

2007
dbSNP: rs61734659
rs61734659
PRSS2
0.010 GeneticVariation BEFREE The heterozygous p.G191R variant was found in three of 241 (1.2%) patients with chronic pancreatitis, in seven of 174 (4.0%) patients with acute pancreatitis, and in 12 of 189 (6.3%) patients with pancreatic neoplasm. 19052022

2009
dbSNP: rs748405415
rs748405415
PRSS2
0.010 GeneticVariation BEFREE The heterozygous p.G191R variant was found in three of 241 (1.2%) patients with chronic pancreatitis, in seven of 174 (4.0%) patients with acute pancreatitis, and in 12 of 189 (6.3%) patients with pancreatic neoplasm. 19052022

2009
dbSNP: rs1057520011
rs1057520011
TTK
T 0.700 GeneticVariation CLINVAR Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM). 20581473

2010
dbSNP: rs1057520013
rs1057520013
STK33
C 0.700 GeneticVariation CLINVAR Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM). 20581473

2010
dbSNP: rs756231248
rs756231248
NEK8
C 0.700 GeneticVariation CLINVAR Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM). 20581473

2010
dbSNP: rs786202134
rs786202134
STK11
G 0.700 GeneticVariation CLINVAR mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome. 21189378

2011
dbSNP: rs786202134
rs786202134
STK11
A 0.700 GeneticVariation CLINVAR mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome. 21189378

2011
dbSNP: rs169068
rs169068
SSTR5 ; SSTR5-AS1
0.010 GeneticVariation BEFREE No somatic mutations were identified, but 3 nonsynonymous SSTR5 SNPs (P109S, L48M, and P335L) in pancreatic tumors were identified. 21692047

2011
dbSNP: rs2066827
rs2066827
CDKN1B ; GPR19
0.010 GeneticVariation BEFREE CDKN1B also harbors single nucleotide polymorphisms; the T/G transversion at nucleotide 326 (the V109G variant) has been reported to be protective in breast, hereditary prostate, and pancreatic tumors. 21177330

2011
dbSNP: rs4988483
rs4988483
SSTR5 ; SSTR5-AS1
0.010 GeneticVariation BEFREE No somatic mutations were identified, but 3 nonsynonymous SSTR5 SNPs (P109S, L48M, and P335L) in pancreatic tumors were identified. 21692047

2011
dbSNP: rs1444669684
rs1444669684
CDKN2A ; CDKN2B-AS1
0.030 GeneticVariation BEFREE In LSL-Kras(G12D)/Pdx-1-Cre/Ink4a/Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor-free survival. 23980075

2013
dbSNP: rs121913529
rs121913529
KRAS
0.020 GeneticVariation BEFREE Pancreas-specific disruption of Pik3ca or Rac1, but not Pik3cb, prevented the development of pancreatic tumors in Kras(G12D/+);Ptf1a(Cre/+) mice. 25311989

2014
dbSNP: rs1399364791
rs1399364791
CDK2 ; PMEL
0.010 GeneticVariation BEFREE Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. 25050737

2014
dbSNP: rs752021744
rs752021744
PIK3CB
0.010 GeneticVariation BEFREE Pancreas-specific disruption of Pik3ca or Rac1, but not Pik3cb, prevented the development of pancreatic tumors in Kras(G12D/+);Ptf1a(Cre/+) mice. 25311989

2014
dbSNP: rs764664272
rs764664272
MMP2
0.010 GeneticVariation BEFREE Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. 25050737

2014
dbSNP: rs1444669684
rs1444669684
CDKN2A ; CDKN2B-AS1
0.030 GeneticVariation BEFREE We disrupted Acvr1b specifically in pancreata of mice (Acvr1b(flox/flox);Pdx1-Cre mice) and crossed them with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreatic tumors. 26408346

2016
dbSNP: rs121913529
rs121913529
KRAS
0.020 GeneticVariation BEFREE We disrupted Acvr1b specifically in pancreata of mice (Acvr1b(flox/flox);Pdx1-Cre mice) and crossed them with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreatic tumors. 26408346

2016
dbSNP: rs200081710
rs200081710
TNIP3
0.010 GeneticVariation BEFREE Listeria also penetrated the transgenic KPC (conditionally express endogenous Kras-G12D and p53-R172H mutant alleles) pancreatic tumors and metastases. 28186976

2017
dbSNP: rs121913444
rs121913444
EGFR
0.010 GeneticVariation BEFREE Pyrosequencing of the primary pancreatic tumor antecedent to metastasis showed an uncommon EGFR mutation at L861Q in the kinase domain of exon 21. 29695402

2018