Gene: GCH1 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11158026
rs11158026
GCH1
0.730 GeneticVariation BEFREE GCH1 rs11158026 was also found to increase the risk of PD. 29724574

2018
dbSNP: rs11158026
rs11158026
GCH1
C 0.730 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci. 28892059

2017
dbSNP: rs11158026
rs11158026
GCH1
0.730 GeneticVariation BEFREE Our findings first demonstrated that VPS13C rs2414739, MIR4697 rs329648, GCH1 rs11158026, and SIPA1L2 rs10797576 do not confer a significant risk for PD in Chinese population. 26678010

2016
dbSNP: rs11158026
rs11158026
GCH1
0.730 GeneticVariation BEFREE Under additive model, the GCH1 rs11158026</span> increased the risk of developing PD (OR = 1.30, 95% CI = 1.10, 1.54, p = 0.002). 26804608

2016
dbSNP: rs11158026
rs11158026
GCH1
0.730 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965

2016
dbSNP: rs11158026
rs11158026
GCH1
C 0.730 GeneticVariation GWASCAT Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. 25064009

2014
dbSNP: rs841
rs841
GCH1
0.010 GeneticVariation BEFREE A common haplotype, tagged by rs841, was associated with a reduced risk for PD (OR = 0.71, 95% CI = 0.61-0.83, p = 1.24 × 10<sup>-4</sup>), and with increased GCH1 expression in brain regions relevant for PD (www.gtexportal.org). 30314816

2019
dbSNP: rs770547722
rs770547722
GCH1
0.010 GeneticVariation BEFREE For GCH1 gene, one known variant (c.239G > A, p.S80N) was detected in a patient who was diagnosed with PD clinically. 29724574

2018